Senior Upstream Biotechnologist - Vaccine Manufacturing

anter consulting pte. ltd.; Singapore; On-site; SGD 90,000 - 130,000; Full time

Job summary

A global life sciences company in Singapore is seeking a Senior Biotechnologist to join its upstream processing team on a major vaccine programme. You will participate in equipment commissioning and start-up, then transition to routine manufacturing as the facility moves to operations.

This is a non-shift, standard office hours role in Singapore. Key responsibilities include commissioning/qualification of upstream equipment, participating in FAT/SAT, drafting batch records, and driving

Qualifications

• Degree or Diploma in Biotechnology, Bioprocess Engineering, Chemical Engineering, Life Sciences or related discipline.
• Minimum 3 years in GMP biopharmaceutical or vaccine manufacturing with substantial upstream experience.
• Experience in fermentation or cell culture and related upstream unit operations.
• Direct involvement in equipment commissioning, qualification or facility start-up, including water runs or engineering runs.
• Practical MES experience such as authoring, reviewing or testing electronic batch records.
• Experience drafting and revising batch records, SOPs and work instructions.
• Strong knowledge of GMP, GDP and data integrity.
• Experience leading deviation investigations and supporting CAPA and change control.

Responsibilities

• Support commissioning and qualification of upstream equipment (fermenters, bioreactors, centrifuges, media prep, seed train).
• Participate in FAT, SAT, walkdowns, punch list, IQ/OQ as user representative.
• Handle water runs, engineering runs, demonstration batches and PPQ batches, incl. sampling and data collection.
• Draft and revise batch records, work instructions and SOPs for new upstream ops.
• Build and review MES recipes and electronic work instructions for GMP compliance.
• Execute upstream manufacturing to schedule (media prep, seed train, fermentation, harvest, centrifugation).
• Operate and monitor process equipment and automation systems; troubleshoot issues.
• Lead deviation investigations and support CAPA and change control.
• Drive continuous improvement in cycle time, yield and right-first-time performance.
• Train junior biotechnologists and deputise for shift lead; support handover and audit readiness.

Skills

GMP knowledge

Upstream bioprocessing

Fermentation

Cell culture

Data integrity

CAPA & Change Control

Training juniors

Documentation

Education

Biotechnology / Bioprocess Engineering degree

Tools

DeltaV

Siemens PCS7

MES systems

Job description

A global life sciences company in Singapore is seeking a Senior Biotechnologist to join its upstream processing team on a major vaccine programme. You will participate in equipment commissioning and start-up, then transition to routine manufacturing as the facility moves to operations.

This is a non-shift, standard office hours role in Singapore. Key responsibilities include commissioning/qualification of upstream equipment, participating in FAT/SAT, drafting batch records, and driving