Scientist (XY Lab), IMCB (3331)

A*STAR RESEARCH ENTITIES; Singapore; On-site; SGD 80,000 - 120,000; Full time

Job summary

A*STAR RESEARCH ENTITIES is seeking a Scientist in Human Stem Cell and Kidney Organoid Research to develop hPSC-derived organoid models for kidney development and disease mechanisms. The role spans stem cell biology, genome engineering, imaging, and animal models, with emphasis on multidisciplinary collaboration.

You will advance organoid and assembloid models, optimise protocols, and contribute to publications, while supporting lab management and cross-team training in a dynamic research

Qualifications

• PhD in Biomedical Sciences or a related discipline is required.
• First-author publications in peer-reviewed journals are advantageous.
• Experience in CRISPR-Cas9 genome editing.
• Experience in hPSC culture and 3D organoid culture.
• Experience in microscopy is preferred.
• Experience in mouse models and animal experiments is advantageous.
• Experience in analysing sequencing data is advantageous.

Responsibilities

• Design and execute in vitro and in vivo experiments with hPSC-derived kidney organoids and assembloids.
• Develop and optimize organoid engineering, differentiation, and imaging workflows.
• Perform tissue collection, molecular analyses, and data interpretation.
• Collaborate with PI and team; contribute to manuscripts and grant proposals.
• Train students and junior staff; assist with lab management and safety tasks.
• Contribute to regulatory compliance and maintenance of shared resources.
• Undertake additional research and administrative duties as assigned.

Skills

Stem cell biology

3D organoid culture

Genome editing (CRISPR-Cas9)

Microscopy

Animal experimentation

NGS data analysis

English communication

Education

PhD in Biomedical Sciences or related

Job description

Position: Scientist – Human Stem Cell and Kidney Organoid Research

The successful candidate will join the Xia Laboratory at the Institute of Molecular and Cell Biology (IMCB), A*STAR, to develop and apply human pluripotent stem cell (hPSC)-derived organoid models to investigate kidney development, human kidney diseases, and therapeutic strategies. The role involves multidisciplinary research integrating stem cell biology, genome engineering, molecular and cellular biology, advanced imaging, and animal models. The candidate will contribute to ongoing research projects, scientific publications, collaborative activities, and laboratory management.

Education

PhD in Biomedical Sciences or a related discipline.

Requirements

• PhD in Cell Biology, Biochemistry, Molecular Biology, Stem Cell Biology, or a related discipline. First-author publications in peer-reviewed journals are an advantage.
• Experience in cell and molecular biology, biochemistry, and CRISPR-Cas9 genome editing.
• Experience in human embryonic stem cell/induced pluripotent stem cell culture and/or 3D organoid culture.
• Experience in microscopy. Knowledge of pathology and histology is an advantage.
• Experience in handling mouse models and conducting animal experiments. Animal surgery and mouse embryonic dissection experience are advantageous.
• Experience in analysing next-generation sequencing datasets is an advantage.
• Good organisational and communication skills, with proficiency in spoken and written English.
• Highly motivated, responsible, willing to learn, and able to work independently and collaboratively in a multidisciplinary research environment.

Job description

The successful candidate will contribute to research projects in the Xia Laboratory focused on developing and applying hPSC-derived kidney organoid models to investigate kidney development, disease mechanisms, and therapeutic strategies.

The candidate will design and conduct in vitro and in vivo experiments involving stem cell culture and differentiation, organoid and assembloid engineering, genome editing, molecular and cellular biology, advanced imaging, and animal models. The role includes optimising experimental protocols, troubleshooting technical challenges, and analysing and interpreting research data.

The candidate will work closely with the Principal Investigator and laboratory members, contribute to collaborative research activities and scientific publications, and assist with laboratory management and administrative duties.

Key responsibilities

• Design, plan, and conduct in vitro and in vivo experiments to support ongoing research projects.
• Develop and optimise experimental approaches involving hPSC culture, kidney organoid and assembloid models, genome editing, molecular and cellular biology, and imaging.
• Conduct animal experiments, including mouse handling, experimental procedures, tissue collection, and downstream analyses, in accordance with institutional guidelines.
• Analyse and interpret experimental data, troubleshoot technical challenges, and maintain accurate research records.
• Contribute to scientific manuscripts, research reports, presentations, and grant applications.
• Participate in collaborative research activities and assist in training students and junior laboratory members, where appropriate.
• Support laboratory management, regulatory compliance, and maintenance of shared research resources.
• Perform other research- and administrative-related duties assigned by the Principal Investigator.