Research Fellow (Organic Chemistry)

Nanyang Technological University Singapore; Singapore; Vor Ort; SGD 70.000 - 90.000; Vollzeit

Zusammenfassung

Nanyang Technological University Singapore is seeking a Research Fellow in Organic Chemistry to develop, synthesize, characterize and purify ADCs, peptides and related components. The role emphasizes solution-phase synthesis, SPPS, conjugation and purification workflows with rigorous analytical characterization.

The successful candidate will deliver reproducible results, optimize amide-bond formation and conjugation, and document findings while collaborating with a multidisciplinary team within

Qualifikationen

• PhD in Chemistry or related field with hands-on synthetic organic chemistry experience.
• Experience in synthesis and purification of antibody-drug conjugates; linker-payload chemistry and bioconjugation required.
• Hands-on SPPS experience including resin handling, coupling cycles, cleavage and LC-MS analysis.
• Experience with amide bond formation and conjugation methods, including reagent selection and protecting groups.
• Experience with ADC purification/characterization using SEC/FPLC, HIC, LC-MS, HPLC/UPLC and UV-Vis.
• Strong documentation, problem-solving, scientific writing and oral communication skills.
• Ability to work independently and collaborate in a multidisciplinary team.

Aufgaben

• Design and execute multi-step solution-phase synthesis and SPPS of peptides, linkers, payloads and ADC-related molecules.
• Develop and optimize conjugation and purification workflows to meet project specs.
• Purify peptides, small molecules, intermediates, linker-payloads and ADCs using chromatography.
• Characterize products for identity, purity, DAR and aggregation using NMR, LC-MS, HPLC/UPLC, UV-Vis, SEC.
• Troubleshoot chemistry and purification steps and propose practical solutions.
• Maintain accurate experimental records and prepare reports and manuscripts.
• Maintain good lab safety and assist with related duties as needed.

Kenntnisse

Synthetic organic chemistry

Bioconjugation

SPPS

Analytical characterization

Problem-solving

Scientific writing

Oral communication

Independent work

Team collaboration

Ausbildung

PhD in Chemistry

Tools

SPPS

LC-MS

NMR

HPLC

UPLC

SEC/FPLC

HIC

UV-Vis

Preparative HPLC

Jobbeschreibung

The School of Chemistry, Chemical Engineering and Biotechnology (CCEB) conducts interdisciplinary education and research across chemistry, chemical engineering and biotechnology, with research strengths that include synthetic, biological and medicinal chemistry.

We are looking for a Research Fellow in Organic Chemistry to develop, synthesize, characterize and purify antibody-drug conjugates (ADCs), peptides and related linker-payload components. The role will focus on solution-phase synthesis, solid-phase peptide synthesis (SPPS), conjugation and purification workflows, analytical characterization, and the delivery of reproducible research results.

Key Responsibilities

• Design and execute multi-step solution-phase organic synthesis and solid-phase peptide synthesis (SPPS) of peptides, linkers, payloads, linker-payloads and other ADC-related molecules.
• Develop and optimize amide-bond formation and conjugation reactions, including coupling-reagent selection, protecting-group strategies, chemoselectivity, conversion and yield.
• Develop and optimize ADC conjugation and purification workflows to produce material that meets project specifications.
• Purify peptides, small molecules, intermediates, linker-payloads and ADCs using flash chromatography, preparative HPLC, SEC/FPLC and other suitable methods.
• Characterize products and assess identity, purity, drug-to-antibody ratio and aggregation using NMR, LC-MS, HPLC/UPLC, UV-Vis, SEC and HIC.
• Troubleshoot amide coupling, SPPS, conjugation, purification and analytical issues, and recommend practical solutions.
• Maintain accurate experimental records and prepare technical reports, presentations and manuscripts.
• Maintain good research and laboratory safety practices and perform related duties assigned by the Principal Investigator.

Job Requirements

• PhD in Chemistry, Chemical Biology or Biochemistry.
• Demonstrated hands-on experience in synthetic organic chemistry and in the synthesis and purification of antibody-drug conjugates; linker-payload chemistry and bioconjugation experience is required.
• Hands-on experience with SPPS, including resin handling, coupling cycles, cleavage, deprotection, preparative HPLC purification and LC-MS analysis.
• Experience developing amide-bond formation and conjugation methods, including coupling-reagent selection, protecting-group strategies, reaction optimization and chemoselectivity.
• Experience with ADC purification and characterization using SEC/FPLC, HIC, LC-MS, analytical HPLC/UPLC and UV-Vis, including assessment of purity, drug-to-antibody ratio and aggregation.
• Good experimental documentation, problem-solving, scientific writing and oral communication skills.
• Ability to work independently and collaborate effectively in a multidisciplinary research team.

We regret that only shortlisted candidates will be notified.

Hiring Institution: NTU