Regulatory Affairs Manager (ASEAN)

Palico Biotech Pte Ltd

Singapore

On-site

SGD 80,000 - 120,000

Full time

14 days+

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Benefits offered by this job

Competitive salary

Equity packages

Opportunities for growth

Job summary

Palico Biotech Pte Ltd in Singapore seeks a Regulatory Affairs Manager to lead the genetic design of their OmniCell™ platform. You'll develop protocols for silencing HLA molecules and oversee a team of researchers, ensuring compliance with safety protocols.

The ideal candidate holds a PhD in a relevant field and has 5+ years of experience in mammalian cell engineering. Join a cutting-edge biotech firm making significant impacts in healthcare.

Qualifications

Minimum 5 years of hands‑on experience in mammalian cell engineering.
Experience with non‑viral delivery methods is highly preferred.
Deep understanding of the biology of MSCs.

Responsibilities

Lead the development of protocols for silencing HLA Class I and II molecules.
Conduct high‑throughput flow cytometry to verify edit efficiency.
Supervise a team of junior researchers and lab technicians.

Skills

CRISPR-Cas12b development

Flow cytometry

T-cell provocation assays

Bioinformatics tools

Education

PhD in Molecular Biology, Immunology, or Cell Biology

Tools

Automated liquid handling systems

NGS (Next‑Generation Sequencing)

Job description

As a Regulatory Affairs Manager at Palico Biotech, you will lead the genetic architecture of our OmniCell™ platform. Your primary objective is to engineer “off-the-shelf” mesenchymal stem cells (MSCs) that remain invisible to the host immune system. You will oversee the design and execution of multiplexed gene‑editing strategies to silence MHC/HLA markers while ensuring the long‑term genomic stability and therapeutic potency of the modified cells.

Key Responsibilities

Genetic Design: Lead the development of CRISPR‑Cas12b and base‑editing protocols for silencing HLA Class I and II molecules.
Validation: Conduct high‑throughput flow cytometry and NGS (Next‑Generation Sequencing) to verify edit efficiency and off‑target profiles.
Functional Assays: Design in vitro T‑cell provocation assays to validate the immune‑evasive properties of engineered lines.
Team Leadership: Supervise a team of junior researchers and lab technicians, ensuring adherence to project timelines and safety protocols.
IP Documentation: Draft technical reports and patents to secure Palico’s proprietary genetic modifications.

Required Qualifications

Education: PhD in Molecular Biology, Immunology, or Cell Biology.
Technical Expertise: Minimum 5 years of hands‑on experience in mammalian cell engineering. Experience with non‑viral delivery methods (electroporation/nanoparticles) is highly preferred.
Industry Knowledge: Deep understanding of the biology of MSCs and the mechanisms of T‑cell‑mediated rejection.
Analytical Skills: Proficiency in bioinformatics tools for genomic analysis and experience with automated liquid handling systems.

Why Join Palico?

Impact: Directly contribute to a platform that eliminates medical waiting lists for critical therapies.
Ecosystem: Work at the heart of Singapore’s Biopolis, surrounded by world‑class infrastructure and collaborative research institutes.
Growth: Competitive salary and equity packages in a Series B startup with a clear path to global commercialization.

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