Associate Principal / Principal Scientist (Protein Science)

Peptideatlas; Singapore; On-site; SGD 180,000 - 260,000; Full time

Job summary

GenScript Biotech Corporation seeks a Principal Scientist in Bispecific Antibody Design & Engineering to lead molecular design strategy and cross-functional execution in Singapore. You will steer platform development, improve expression and manufacturability, and drive client-facing projects with high-quality biologics solutions.

The role requires directing design-for-manufacturability initiatives, collaborating with R&D and manufacturing to ensure tech transfer readiness, and advancing

Qualifications

• Ph.D. in Biochemistry, Molecular Biology, Cell Biology, Structural Biology, Bioengineering or a related field.
• At least 5 years of antibody design, protein expression, and purification experience, preferably in industry.
• Strong expertise in bispecific design and troubleshooting expression challenges.
• Experience with biophysical characterization of proteins and protein-protein interactions.
• Familiarity with automation and high-throughput techniques for protein expression and purification.
• Excellent written and verbal English communication skills with publications and presentations.

Responsibilities

• Biologics Production Leadership: design and engineer complex antibody formats to achieve high yields, purity, and functionality.
• Oversee a team and provide technical guidance in protein science methodologies.
• Partner with QA, Process Development, and Manufacturing to align biologics production workflows.

Education

PhD in Biochemistry / Molecular Biology / Cell Biology / Structural Biology / Bioengineering or related field

Tools

SPR

Mass spectrometry

Automation

Job description

About GenScript

GenScript Biotech Corporation (Stock Code: 1548.HK) is a global biotechnology group. Founded in 2002, GenScript has an established global presence across North America, Europe, the Greater China, and Asia Pacific. GenScript's businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, and cell therapy.

GenScript is committed to striving towards its vision of being the most reliable biotech company in the world to make humans and nature healthier through biotechnology.

Position Overview:

We are seeking a highly motivated and experienced Principal Scientist in Bispecific Antibody Design & Engineering to establish and strengthen Singapore’s role as a center of excellence for complex antibody design and molecular engineering. In this role, you will serve as a functional leader in molecular design, format selection and recommendation, and engineering strategy while enabling improved expression, developability, and manufacturability. Additionally, you will play a key role in client-facing projects, ensuring seamless collaboration and delivery of high-quality biologics solutions. This position requires a blend of platform building, leadership skills, and the ability to build cross effectively.

Key Responsibilities:

Biologics Production Leadership:

• Develop, triage, implement, and troubleshoot innovative strategies for the design and engineering of complex antibody formats (bispecifics, multivalent, Fc-fusions, VHH). to achieve high yields, purity, and functionality.
• Design and manage a portfolio of projects to provide data-driven, structure-function insights to improve expression, stability, and manufacturability.
• Oversee a team of research associates and/or biotechnologists, providing technical guidance and fostering a culture of excellence in protein science methodologies.

Cross-Functional Collaboration:

• Collaborate with cross-functional and cross-cultural teams to support the development of biologics, with a focus on evaluate and translate new technologies into production-ready solutions.
• Periodically review internal and external advancements in:
  • Antibody formats and engineering strategies
  • Upstream and downstream integration impacts driven by molecule design
• Assess readiness of new technologies for tech transfer, including:
  • Fit-for-purpose application across different molecule classes
  • Scalability and reproducibility
  • Impact on quality attributes (aggregation, mispairing, heterogeneity)
  • Act as a scientific bridge between R&D innovation and operational deployment, ensuring:
    1. New platforms are not only scientifically sound but also translatable to production workflows
    2. Design decisions are aligned with manufacturing realities
• Partner with internal stakeholders (e.g., Quality Assurance, Process Development, and Manufacturing) to ensure alignment and efficiency in biologics production workflows.

Develop design-for-manufacturability strategies and internal guidelines:

• Develop and integrate AI-assisted design-for-manufacturability frameworks, leveraging internal datasets and external computational tools (e.g., structure prediction, developability scoring) to proactively identify and mitigate risks such as aggregation, mispairing, and low expression in complex antibody formats.
• Lead or support AI-enabled design and innovation initiatives (internal and external partnerships, including governmental or consortium projects) by translating computational design outputs into experimentally validated constructs, and ensuring alignment between in silico design predictions and real-world expression, quality, and manufacturability outcomes.

Innovation & Intellectual Property:

• Generate novel ideas and contribute to the company’s intellectual property portfolio by drafting scientific papers, filing patents and reporting innovations in scientific forums.
• Contribute to the development of scientific publications, conference presentations, and webinars to showcase innovative findings and advancements.
• Prepare and review technical reports and documentation to internal and external stakeholders.

Qualifications and Preferred Skills:

• Ph.D., in Biochemistry, Molecular Biology, Cell Biology, Structural Biology, Bioengineering or a related field.
• At least 5 years of experience in antibody design, protein expression, and purification, preferably in an industrial setting.
• Strong expertise in bispecific design and troubleshooting expression challenges.
• A demonstrated record of success with protein engineering for enhanced protein expression or properties.
• Experience with the biophysical characterization of proteins and the assessment of protein-protein interactions.
• Familiarity with automation and high-throughput techniques for protein expression and purification.
• Strong analytical and problem-solving skills, with a wide ranging experience in analytical techniques such as SPR, and mass spectrometry.
• Excellent written and verbal English communication skills, with a track record of scientific publications, presentations, and conferences.

GenScript USA Inc/ProBio Inc. is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is the Company's policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.

GenScript USA Inc./ProBio Inc. maintains a drug-free workplace.

Please note: Genscript USA Inc./ProBio Inc. will only contact candidates through verified application sources. GenScript/Probio does not request personal information from candidates through individual email or any other platform.