Antibody Scientist Early Discovery

Barrington James; Singapore; On-site; SGD 120,000 - 190,000; Full time

Job summary

Barrington James is recruiting an Antibody Scientist - Early Discovery for an RNAi/siRNA therapeutics client in Singapore. You will lead discovery and optimization of antibodies for AOC/PCC conjugates targeting extrahepatic tissues, driving programs from early discovery to nomination.

The role requires 5+ years in industry with PhD in relevant field, deep experience in antibody discovery, engineering, and characterization, plus cross-site collaboration with our Suzhou team and CRO partners.

Qualifications

• Ph.D. in Molecular Biology, Immunology, or Protein Engineering with 5+ years in industry.
• Proven expertise in antibody discovery technologies and engineering for therapeutics.
• Experience in antibody characterization including kinetics, functional assays, and epitope analysis.
• Direct experience with AOC/PCC modalities or conjugate technologies preferred.

Responsibilities

• Lead discovery and screening of antibodies for extrahepatic targeting using discovery platforms.
• Design and execute engineering strategies to optimize affinity, specificity, developability.
• Perform antibody characterization including binding affinity, epitope analysis, cross-reactivity.

Skills

Antibody engineering

Antibody discovery

Cross-functional collaboration

Protein biochemistry

Molecular biology

Education

Ph.D. in Molecular Biology/Immunology/Protein Engineering

Tools

Antibody discovery platforms

Job description

I am currently looking for a Antibody Scientist - Early Discovery for one of my R&D client specialized in RNAi and siRNA therapeutics development.

Job Title: Antibody Scientist - Early Discovery

Type: Full Time

The Antibody Scientist will lead the discovery and optimization of antibodies for AOC/PCC conjugates targeting extrahepatic tissues, applying strong expertise in antibody engineering and characterization to drive programs from early discovery to PCC nomination.

Responsibilities

• 1. Lead the discovery and screening of antibodies for extrahepatic targeting applications, using established antibody discovery platforms and technologies.
• Design and execute antibody engineering strategies to optimize affinity, specificity, and developability properties for AOC/PCC conjugates.
• Perform comprehensive antibody characterization including binding affinity assessment, epitope analysis, and cross-reactivity profiling.
• 4. Collaborate closely with Senior Chemist and Senior Biologist teams to co-develop and optimize new AOC/PCC platforms for extrahepatic targeting.
• Establish and maintain a seamless and effective working model with the Suzhou discovery team, including regular scientific alignment, joint experimental design, transparent data sharing, and synchronized project timelines to ensure efficient cross-site collaboration.
• Manage external CRO collaborations for antibody discovery and characterization, including study design oversight, quality control, data review, and timeline management.
• Drive innovation in antibody discovery workflows and contribute to IP generation and scientific publications.

Requirements:

• Ph.D. in Molecular Biology, Immunology, Protein Engineering, or a related discipline with minimum 5 years of industry experience in antibody discovery and engineering.
• Demonstrated industry expertise in antibody discovery technologies and antibody engineering for therapeutic applications.
• Proven experience in antibody characterization including binding kinetics analysis, functional assays, and binding site characterization.
• Direct experience with AOC/PCC modalities or conjugate technologies in an industry setting is highly preferred.
• Strong hands-on skills in molecular biology and protein biochemistry techniques relevant to antibody development.
• Proven ability to work effectively in cross-functional, cross-site project teams, with experience in establishing efficient collaboration models across geographically distributed teams.
• Experience in managing external CRO collaborations for antibody discovery and characterization projects.