Senior Scientist – Synthetic Chemist in Oligonucleotide Therapeutics

AstraZeneca; Sweden; On-site; SEK 700,000 - 950,000; Full time

Job summary

AstraZeneca in Gothenburg seeks a Synthetic Chemist to advance oligonucleotide therapeutics. You will design and execute synthetic routes for nucleotide compounds and conjugates, focusing on innovative approaches and rigorous purification/characterization.

Applicants should hold a PhD in Organic Chemistry with hands-on experience in oligonucleotide synthesis, and excel at collaborative, multidisciplinary research within Discovery Sciences. English proficiency and a teamwork mindset are essential.

Qualifications

• PhD in Organic Chemistry with emphasis on synthetic methodologies.
• Experience in oligonucleotide or peptide synthesis is required.
• Ability to design and execute experiments independently.

Responsibilities

• Develop oligonucleotide drugs and related conjugates to support AstraZeneca's pipeline.
• Synthesize and purify nucleotide compounds and characterize products.
• Collaborate across Discovery Sciences to advance oligonucleotide therapeutics.
• Contribute to publication track record through high-quality research.

Skills

Advanced synthetic chemistry

Oligonucleotide synthesis

Autonomous experimental design

Team collaboration

Education

PhD in Organic Chemistry

Job description

Synthetic Chemist Position at AstraZeneca

Are you a passionate synthetic chemist with a great passion for science? Would you like to apply your expertise in synthetic chemistry to develop innovative oligonucleotide therapeutics and make an impact on drug discovery sciences? If yes, we have just the position for you at AstraZeneca, Discovery Sciences in Gothenburg, Sweden!

We are searching for an engaged and talented synthetic chemist with experience in oligonucleotide or peptide synthesis to join our Oligonucleotide Chemistry and Targeted Delivery Team within the Discovery Sciences department at AstraZeneca in Gothenburg, Sweden. In a collaborative environment across therapy areas, you will get the opportunity to apply your expertise in synthetic chemistry to contribute and play a significant role in advancing the oligonucleotide therapeutic field.

We have been curious about oligonucleotides as a new modality since 2012 and our scientific interest has only grown. Therefore, we are now poised to exploit the wealth of expertise from across our R&D units and through a new matrix organization to develop proprietary oligonucleotide therapeutics. We offer a highly rewarding scientific environment along with an inclusive, dynamic, and team-focused atmosphere – with a goal to design and develop the oligonucleotide therapeutics of the future.

What you will do: You will contribute to projects with a focus on developing oligonucleotide drugs to support AstraZeneca pipeline. By applying cutting-edge technologies and methodologies, you will synthesize innovative nucleotide/oligonucleotide compounds conjugated oligonucleotide therapeutics.

As an expert in synthetic chemistry, you will apply your expertise in compound purification and characterization, propose experimental strategies and troubleshoot challenges to succeed in your role. You will also be involved in oligonucleotide synthesis process in close collaboration with the team and other groups at AstraZeneca.

This position offers the opportunity not only to be creative in solving a wide range of synthetic challenges but also to learn advanced techniques and participate in biological evaluation of synthesized compounds through active collaboration with multiple experts across AstraZeneca functions. This strong network of experts will help to ensure a high-impact publication track record. Therefore, the position offers the ability to maintain a competitive research output.

Essential requirements: The successful candidate will demonstrate a passion for driving scientific questions and is a scientifically critical individual capable of receiving and analyzing input from multiple fields and deciding on focused course of action. You should also be able to work independently and have a positive, result-oriented, and problem-solving attitude. Excellent English is required, both spoken and written, and ability to operate effectively in a multi-disciplinary research environment. We also believe that you enjoy teamwork, have a collaborative nature and will be an encouraging colleague to all.

You also have:

• PhD in Organic Chemistry
• Advanced and up to date knowledge in synthetic strategies, techniques and reactions
• Ability to design and execute experiments autonomously
• Knowledge of synthetic chemistry related to oligonucleotides, oligo building blocks and/or synthesis of advanced organic molecules. Knowledge in oligonucleotide therapeutics, design and data analysis is a plus

Desirable requirements:

• Scientific excellence as shown by previous work, publication list or references from scientific mentors
• Post-doc experience

Why AstraZeneca? At AstraZeneca, we follow the science to explore and innovate. We are committed to treating, preventing, modifying and even curing some of the world's most complex diseases. Our team is driven by our desire to understand and reveal new insights. We are always learning from those living with diseases and harnessing digital, data science & AI to fast-forward our research. Join us as we push the boundaries of science to deliver life-changing medicines.

Tagged as: Life Sciences