Senior Scientist – Analytical Method Development, Pharmaceutical Development

AstraZeneca plc; Göteborgs kommun; On-site; SEK 850,000 - 1,200,000; Full time

Job summary

AstraZeneca plc is seeking a Senior Scientist for Analytical Method Development to support robust method development, sample preparation optimisation, and cleaning validation across global product development. You will work with formulation, manufacturing, quality, engineering, and external partners to deliver reliable data.

The role focuses on developing and transferring analytical methods, troubleshooting complex systems, and implementing automation to enhance analytical workflows within a GMP

Qualifications

• MSc, PhD, or equivalent in Analytical Chemistry, Pharmaceutical Sciences or related discipline.
• Proven experience in analytical method development, optimisation, qualification, or validation in pharma or related environment.
• Practical experience with sample preparation techniques (extraction, dilution, filtration, purification).
• Strong knowledge of analytical techniques such as HPLC, UPLC, LC-MS, GC or related methodologies.
• Experience troubleshooting analytical methods and resolving issues (matrix effects, carryover, variability).
• Experience working with CROs or external laboratory partners.
• Strong scientific, organisational, communication, and problem-solving skills.
• Knowledge of GMP, data integrity, and analytical quality requirements.

Responsibilities

• Sample preparation optimisation: Improve extraction, dilution, filtration, and purification procedures.
• Cleaning validation: Develop and validate analytical methods for cleaning verification, including residue recovery, swab or rinse sampling.
• Method development & validation: Design, develop, validate and transfer analytical methods
• Analytical troubleshooting: Provide expert analytical troubleshooting and scientific support across development programmes.
• CRO troubleshooting: Provide technical troubleshooting and scientific support to CROs.
• Automation and robotics: Implement and optimise automated and robotic solutions for sample preparation and workflows.

Skills

Analytical method development

HPLC/UPLC/LC-MS

Troubleshooting analysis

CRO collaboration

Problem solving

Communication

Education

MSc/PhD in Analytical Chemistry or Pharmaceutical Sciences

Tools

HPLC

UPLC

LC-MS

GC

Job description

Are you passionate about analytical science, method development, and innovative laboratory solutions? Do you enjoy solving complex technical challenges and applying new technologies to improve analytical workflows?

Pharmaceutical Technology and Development (PT&D) sits within Operations and is the organization that turns brilliant science into actual medicines that help millions of people. We work across the entire value chain, designing and delivering active ingredients, formulations and devices for new medicines and providing expert technical support to all AstraZeneca’s commercial drug substances and products to ensure we successfully supply medicines to patients.

We are seeking an experienced and innovative Senior Scientist to support analytical method development activities within Global Product Development.

As a Senior Scientist in Analytical Method Development, you will work with colleagues across formulation, manufacturing, quality, engineering, and external partner organisations to develop robust analytical methods, optimise sample preparation and cleaning validation approaches.

What You Will Do

Sample preparation optimisation: Improve extraction, dilution, filtration, and purification procedures.

• Cleaning validation: Develop and validate analytical methods for cleaning verification, including residue recovery, swab and/or rinse sampling.
• Method development & validation: Design, develop, validate and transfer analytical methods
• Analytical troubleshooting: Provide expert analytical troubleshooting and scientific support across pharmaceutical development programmes, applying separation science expertise to investigate method performance issues, resolve complex analytical challenges, and deliver timely, reliable data to support programme objectives.
• CRO troubleshooting: Provide technical troubleshooting and scientific support to contract research organisations, resolving analytical challenges and supporting successful study delivery.
• Automation and robotics: Implement and optimise automated and robotic solutions for sample preparation, analytical workflows, and cleaning validation activities.

Essential Requirements

• MSc, PhD, or equivalent experience in Analytical Chemistry, Pharmaceutical Sciences or a related scientific discipline.
• Proven experience in analytical method development, optimisation, qualification, or validation within a pharmaceutical, or related environment.
• Practical experience with sample preparation techniques, including extraction, dilution, filtration and purification.
• Strong knowledge of analytical techniques such as HPLC, UPLC, LC-MS, GC, or related methodologies.
• Work experience in troubleshooting analytical methods and resolving issues such as matrix effects, carryover, variability, and atypical results.
• Experience working with CROs or external laboratory partners.
• Strong scientific, organisational, communication, and problem-solving skills.
• Knowledge of GMP, data integrity, and relevant analytical quality requirements.

Desired Requirements

• Experience supporting cleaning validation, including swab and rinse sampling, residue recovery, and analytical assessment.
• Experience of advanced structured problem-solving techniques e.g. six sigma
• Fundamental digital and data capability relevant to analytical development, including proficiency with multivariate experimental design and basic DoE concepts for method and process understanding.
• Experience implementing or supporting laboratory automation and robotics.
• Experience with electronic laboratory systems, chromatography data systems, statistical tools, or laboratory workflow platforms.
• Experience working in a global, cross-functional, or matrix organisation.
• Experience preparing or reviewing analytical protocols, reports, validation documentation, or technical assessments.

At AstraZeneca, we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare.

Date Posted

22-okt.-2026

Closing Date

01-nov.-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.