Senior Scientist Process Engineer - Pharmaceutical Product Development

AstraZeneca plc; Göteborgs kommun; Presencial; GBP 60.000 - 90.000; Jornada completa

Descripción de la vacante

AstraZeneca plc in Macclesfield seeks a Senior Scientist Process Engineer to design, develop and optimize robust manufacturing processes for oral and parenteral drug products. The role blends hands-on laboratory work with modelling, digital tools and technology transfer to late-stage development.

You will lead experimental studies, scale-up activities and cross-functional collaboration to ensure regulatory readiness and efficient timelines, in a fast-paced pharmaceutical environment.

Formación

• PhD in Chemical Engineering, Applied Physics or a related scientific discipline, or MSc with significant industrial experience in pharmaceutical process development.
• Hands-on laboratory experience, including experimental design, data generation and interpretation to support process understanding and development.
• Demonstrated experience in pharmaceutical process development within CMC, including the design, development and optimisation of drug product manufacturing processes for oral solid dosage forms and/or parenteral products.
• Strong understanding of CMC regulatory requirements, with experience preparing regulatory documentation to support clinical development and/or marketing applications.
• Experience applying modelling, simulation and digital technologies to support process understanding, development and decision-making.
• Strong scientific problem-solving skills, with the ability to analyse data, interpret results, and make sound technical decisions.
• Strong collaboration and communication skills, with the ability to work effectively across multidisciplinary teams.
• Ability to work effectively in a global, cross-functional environment and build strong collaborative relationships across disciplines.
• Excellent written and spoken English.

Responsabilidades

• Lead design, development and optimization of robust manufacturing processes for oral and parenteral drug products.
• Design, execute and interpret laboratory studies to build process understanding and generate data.
• Scale up and transfer processes for commercial manufacturing of oral solids and parenteral products.
• Apply modelling, simulation and digital tools to guide strategy and accelerate timelines.
• Champion digital approaches that enhance process development and data integrity.
• Collaborate with formulation scientists, engineers, and manufacturing experts to solve technical challenges.
• Plan and deliver technical activities to agreed timelines with sound engineering judgement.
• Contribute to scientific networks and keep aware of emerging methods and technologies.

Conocimientos

Hands-on lab work

Process development

Modelling & simulation

Data analysis

English communication

Educación

PhD in Chemical Engineering or Applied Physics

Herramientas

AI-enabled tools

Automated manufacturing systems

Descripción del empleo

Job Title: Senior Scientist Process Engineer - Pharmaceutical Product Development

Location: Macclesfield

Salary: Competitive

Introduction to role

Are you ready to turn cutting-edge science into dependable, scalable manufacturing that delivers medicines to patients sooner? Do you thrive at the bench and at the whiteboard, pairing experiments with models to make confident, high-impact decisions? Based in Gothenburg, you will be a laboratory-based senior scientist who combines hands-on experimentation with modelling, simulation and digital tools to create robust processes for oral and parenteral drug products in late-stage development.

Accountabilities

• Process Design and Optimization: Lead the design, development and optimization of robust manufacturing processes for oral and parenteral drug products, ensuring long-term performance and patient needs are met.
• Experimental Process Understanding: Design, execute and interpret laboratory studies to build deep process understanding and generate decision-enabling data.
• Scale-Up and Technology Transfer: Contribute within cross-functional teams to develop, scale and transfer reliable commercial manufacturing processes for oral solid dosage forms and parenteral products.
• Modelling and Simulation: Apply modelling, simulation and digital tools to guide experimental strategy, quantify risk and accelerate development timelines.
• Digital Enablement: Champion and advance digital approaches that enhance pharmaceutical process development and strengthen data integrity and reuse.
• Data-Driven Collaboration: Build strong partnerships with formulation scientists, engineers, modelling and simulation specialists, and manufacturing experts to solve complex technical challenges.
• Technical Planning and Delivery: Independently plan and deliver technical activities to agreed timelines and quality standards, applying sound engineering judgement to interpret results and adapt strategies.
• Scientific Networking and Foresight: Contribute to scientific and technology networks, maintaining awareness of emerging methods and technologies relevant to pharmaceutical product development.

Essential Skills/Experience

• PhD in Chemical Engineering, Applied Physics or a related scientific discipline, or an MSc with significant industrial experience in pharmaceutical process development.
• Hands-on laboratory experience, including experimental design, data generation and interpretation to support process understanding and development.
• Demonstrated experience in pharmaceutical process development within CMC, including the design, development and optimisation of drug product manufacturing processes for oral solid dosage forms and/or parenteral products.
• Strong understanding of CMC regulatory requirements, with experience preparing regulatory documentation to support clinical development and/or marketing applications.
• Experience applying modelling, simulation and digital technologies to support process understanding, development and decision-making.
• Strong scientific problem-solving skills, with the ability to analyse data, interpret results, and make sound technical decisions.
• Strong collaboration and communication skills, with the ability to work effectively across multidisciplinary teams.
• Ability to work effectively in a global, cross-functional environment and build strong collaborative relationships across disciplines.
• Excellent written and spoken English.

Desirable Skills/Experience

• Experience leading engineering work packages, process development activities or technology transfer projects within pharmaceutical development.
• Experience of commercial process development and technology transfer for new chemical entities.
• Experience of continuous processing in a pharmaceutical environment.
• Knowledge of GMP, Process Safety, Data Integrity and Change Control requirements.
• Experience working with automated manufacturing systems and digitalised process development environments.
• Experience working with CDMOs and outsourced development activities.
• Experience exploring or applying AI-enabled tools within pharmaceutical development.

Why AstraZeneca

Join a community where scientists, engineers and digital specialists work side by side to move molecules to medicines with pace and precision. You will influence how a diverse pipeline is developed and manufactured, from high-tech labs to modern production lines that apply lean thinking, automation and advanced analytics. Here, unexpected combinations of expertise come together to test bold ideas, learn fast and scale what works, all within a cul