Scientist Clinical Pharmacologist

Tecnimede Group; Sintra; Presencial; EUR 55 000 - 75 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Health insurance

Life insurance

Resumo da oferta

Tecnimede Group, a pharmaceutical company in Portugal, seeks a Scientist Clinical Pharmacologist to define clinical development programs and lead trial designs focused on pain management and neuropsychiatric disorders.

The ideal candidate will possess a PharmD, PhD, or MD, with at least 3 years of industry experience. This role offers a competitive package including health and life insurance in a scientifically driven environment.

Qualificações

• Strong foundation in clinical pharmacology or related disciplines.
• 3+ years of experience in clinical pharmacology or development.
• Experience with trial designs for regulatory submission.

Responsabilidades

• Define drug development programs and strategies.
• Design and lead clinical studies in pain and neuropsychiatric disorders.
• Analyze complex clinical data and identify drug-drug interactions.

Conhecimentos

Clinical pharmacology

Pharmacometric analysis

Trial design

Regulatory submission knowledge

Communication skills

Formação académica

PharmD, PhD, or MD

Descrição da oferta de emprego

At Tecnimede Group, we are driven by a clear purpose: improving people's lives through medical science and technology.

As a Portuguese multinational pharmaceutical company with a presence in six countries and products reaching more than 100 markets worldwide, we offer the opportunity to contribute to a business with global impact while building your career from Portugal.

We believe that great ideas can come from anywhere. That's why we foster a collaborative environment where initiative is valued, innovation is encouraged, and people are empowered to challenge existing ways of working and help shape the future of our organisation.

Joining Tecnimede means becoming part of a company that invests in growth — not only through science and technology, but also through its people. Here, you will find opportunities to learn, develop, and build a meaningful career while contributing to a purpose that makes a difference every day.

If you are looking for a role where your work can create real impact, join us in elevating lives worth living.

Scientist Clinical Pharmacologist

Key Responsibilities

• Define the clinical and nonclinical drug development programs, building up the strategies to bridge the gap between preclinical data and proof of concept (POC) clinical studies (translational research);
• Design clinical pharmacology and efficacy studies in chronic and neuropathic pain (e.g., enriched enrollment randomized withdrawal, crossover, adaptive, and platform designs), and neuropsychiatric disorders (with special emphasis in treatment-resistant depression), selecting endpoints and outcome measures appropriate to the therapeutic indications;
• Lead dose selection and dose-justification strategy using PK/PD, exposure-response, and population modelling approaches; calculating safe and effective human doses based on preclinical data and managing dose escalation strategies;
• Provide mechanistic and quantitative input on drug-drug interaction risk, special populations, and abuse-deterrent or opioid-sparing considerations where relevant;
• Data interpretation: analyzing complex clinical data to identify drug-drug interactions and the impact of factors like age or organ dysfunction;
• Anticipate and mitigate placebo response and assay sensitivity challenges characteristic of pain and treatment-resistant depression trials;
• Author and review key documents such as the Investigator's Brochure (IB), clinical pharmacology sections of protocols and protocol synopsis; Investigator Medicinal Product Dossier (IMPD) and clinical and nonclinical overviews and summaries (submodules) of the Common Technical Document (MAAs);
• Represent Clinical Pharmacology in interactions with EMA, FDA and other health authorities, including scientific advice meetings;

Required Qualifications

• PharmD, PhD, or MD with a strong foundation in clinical pharmacology, pharmacometrics, or a related quantitative discipline;
• 3+ years of industry experience in clinical pharmacology or clinical development, with direct involvement in pain and/or neuropsychiatric disorders development programs;
• Demonstrated experience designing trials for regulatory submission under EMA and/or FDA frameworks;
• Strong working knowledge of PK/PD modelling, exposure-response analysis, and translational pharmacology;
• Track record contributing to successful health authority interactions and regulatory filings;
• Excellent written and verbal communication skills (in English), with the ability to influence cross‑functional teams.

Preferred Qualifications

• Direct experience with analgesic or pain-specific endpoints and trial designs (e.g., EERW, conditioned pain modalities, neuropathic pain scales);
• Experience with adaptive or AI‑assisted clinical trial design and feasibility platforms;
• Prior leadership of a Phase 2/3 development programs through to EMA or FDA approval.

What We Offer

• A scientifically driven environment with ownership over trial design strategy;
• Health insurance and life insurance;

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