Postdoc: Computational & Experimental Protein Discovery

The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences; Poland; On-site; PLN 89,000 - 123,000; Full time

Benefits offered by this job

Access to research infrastructure

Employee benefits according to instit.

Job summary

The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences in Warsaw invites applications for a Postdoctoral Researcher to join the lab led by Dr Łukasz Wieteska. The role focuses on protein discovery, molecular interactions and cellular signalling using computational and experimental approaches.

We offer a full-time appointment, a fixed-term contract for 1 year with possible extension, competitive remuneration, and access to state-of-the-art facilities and

Qualifications

• PhD in biochemistry, molecular biology, structural biology, computational biology, bioinformatics or related field.
• Good knowledge in Python and/or other relevant programming languages, with experience using Linux and command-line tools.
• Strong research experience in computational biology of proteins or a closely related discipline.
• Hands-on experience in recombinant protein expression, purification and biochemical characterization.
• Good understanding of protein structure, function and molecular interactions.
• Ability to independently plan experiments or computational analyses, troubleshoot problems and critically interpret scientific data.
• Excellent written and spoken English.
• Strong motivation, scientific curiosity and the ability to work both independently and collaboratively.

Responsibilities

• Computational biology and bioinformatics: Development, optimization and implementation of computational pipelines for protein sequence analysis, structural modelling and protein–protein interaction prediction. This will involve programming and scripting (e.g., Python, Bash), automation of computational workflows, analysis of large biological datasets and use of high-performance computing (HPC) clusters
• Molecular biology: Design and generation of recombinant protein constructs, molecular cloning, mutagenesis and optimisation of expression strategies
• Protein expression and purification: Production of recombinant proteins using bacterial and/or mammalian expression systems, followed by purification and quality assessment
• Cellular and functional assays: Investigation of protein function using mammalian cell culture, reporter assays, immunoblotting, fluorescence microscopy and other cell-based approaches
• The postdoctoral researcher will be encouraged to develop independent scientific ideas, contribute to experimental design and data interpretation, collaborate with other researchers, and participate in the preparation of manuscripts and scientific presentations.

Skills

Python

Computational biology

Bioinformatics

English (written and spoken)

Education

PhD in biochemistry, molecular biology, structural biology, computational biology, bioinformatics or related field

Tools

Linux

HPC

Python scripting

Job description

The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences in Warsaw invites applications for a Postdoctoral Researcher to join the lab led by Dr Łukasz Wieteska. The role focuses on protein discovery, molecular interactions and cellular signalling using computational and experimental approaches.

We offer a full-time appointment, a fixed-term contract for 1 year with possible extension, competitive remuneration, and access to state-of-the-art facilities and