Postdoc in Prof. Łukasz Wieteska group (Sonata Bis 15 - project) 11/2026

The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences; Poland; On-site; PLN 89,000 - 123,000; Full time

Benefits offered by this job

Access to research infrastructure

Employee benefits according to instit.

Job summary

The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences in Warsaw invites applications for a Postdoctoral Researcher to join the lab led by Dr Łukasz Wieteska. The role focuses on protein discovery, molecular interactions and cellular signalling using computational and experimental approaches.

We offer a full-time appointment, a fixed-term contract for 1 year with possible extension, competitive remuneration, and access to state-of-the-art facilities and

Qualifications

• PhD in biochemistry, molecular biology, structural biology, computational biology, bioinformatics or related field.
• Good knowledge in Python and/or other relevant programming languages, with experience using Linux and command-line tools.
• Strong research experience in computational biology of proteins or a closely related discipline.
• Hands-on experience in recombinant protein expression, purification and biochemical characterization.
• Good understanding of protein structure, function and molecular interactions.
• Ability to independently plan experiments or computational analyses, troubleshoot problems and critically interpret scientific data.
• Excellent written and spoken English.
• Strong motivation, scientific curiosity and the ability to work both independently and collaboratively.

Responsibilities

• Computational biology and bioinformatics: Development, optimization and implementation of computational pipelines for protein sequence analysis, structural modelling and protein–protein interaction prediction. This will involve programming and scripting (e.g., Python, Bash), automation of computational workflows, analysis of large biological datasets and use of high-performance computing (HPC) clusters
• Molecular biology: Design and generation of recombinant protein constructs, molecular cloning, mutagenesis and optimisation of expression strategies
• Protein expression and purification: Production of recombinant proteins using bacterial and/or mammalian expression systems, followed by purification and quality assessment
• Cellular and functional assays: Investigation of protein function using mammalian cell culture, reporter assays, immunoblotting, fluorescence microscopy and other cell-based approaches
• The postdoctoral researcher will be encouraged to develop independent scientific ideas, contribute to experimental design and data interpretation, collaborate with other researchers, and participate in the preparation of manuscripts and scientific presentations.

Skills

Python

Computational biology

Bioinformatics

English (written and spoken)

Education

PhD in biochemistry, molecular biology, structural biology, computational biology, bioinformatics or related field

Tools

Linux

HPC

Python scripting

Job description

The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences

Organisation/Company The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences Research Field Biological sciences » Biology Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 15 Dec 2026 - 23:59 (Europe/Warsaw) Country Poland Type of Contract Temporary Job Status Full-time Hours Per Week 40 Offer Starting Date 1 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Reference Number Postdoc__LW_11/2026 Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The International Institute of Molecular Mechanisms and Machines (IMol PAS) is an international research institute in Warsaw working at the interface of molecular biology, biochemistry, biophysics, structural biology and computational biology. We are seeking a motivated and creative Postdoctoral Researcher to join the newly established laboratory led by Dr Łukasz Wieteska.

Group Leader: Dr Łukasz Wieteska
Research Area: Protein Discovery, Molecular Interactions and Cellular Signalling

About the Laboratory and Project

Our laboratory investigates the molecular mechanisms underlying protein interactions and cellular signalling, with a particular interest in the discovery and functional characterisation of biologically active proteins. We combine computational approaches, protein biochemistry, structural biology and cell-based experiments to understand how proteins recognise their molecular partners and regulate biological processes.
The successful candidate will participate in a multidisciplinary research programm combining computational protein analysis and experimental characterization. The project offers opportunities to develop new computational strategies, investigate protein function and explore molecular interactions using complementary biochemical, biophysical and cellular approaches.

Your Role

The successful candidate will contribute to the design, implementation and experimental validation of approaches for protein discovery and characterization. Depending on their expertise, responsibilities will include:

• Computational biology and bioinformatics: Development, optimization and implementation of computational pipelines for protein sequence analysis, structural modelling and protein–protein interaction prediction. This will involve programming and scripting (e.g., Python, Bash), automation of computational workflows, analysis of large biological datasets and use of high-performance computing (HPC) clusters
• Molecular biology: Design and generation of recombinant protein constructs, molecular cloning, mutagenesis and optimisation of expression strategies
• Protein expression and purification: Production of recombinant proteins using bacterial and/or mammalian expression systems, followed by purification and quality assessment
• Cellular and functional assays: Investigation of protein function using mammalian cell culture, reporter assays, immunoblotting, fluorescence microscopy and other cell-based approaches

The postdoctoral researcher will be encouraged to develop independent scientific ideas, contribute to experimental design and data interpretation, collaborate with other researchers, and participate in the preparation of manuscripts and scientific
presentations.
The exact balance between computational and experimental work will depend on the candidate's expertise and the evolving needs of the project.

Essential Qualifications:

• PhD in biochemistry, molecular biology, structural biology, computational biology, bioinformatics or a related field
• Good knowledge in Python and/or other relevant programming languages, with experience using Linux and command-line tools
• Strong research experience computational biology of proteins or a closely related discipline
• Hands-on experience in recombinant protein expression, purification and biochemical characterization
• Good understanding of protein structure, function and molecular interactions
• Ability to independently plan experiments or computational analyses, troubleshoot problems and critically interpret scientific data
• Excellent written and spoken English
• Strong motivation, scientific curiosity and the ability to work both independently and collaboratively

Desirable Qualifications:

• Familiarity with biophysical and structural techniques such as SPR, BLI, NMR or other methods for characterizing protein interactions
• Experience in mammalian cell culture and functional assays, including reporter assays, flow cytometry or fluorescence microscopy

We Offer:

• Full-time postdoctoral employment within an NCN-funded research project
• Fixed-term employment contract for 1 year with the possibility of extension
• Competitive remuneration: approximately ~9500 PLN gross/month
• Opportunity to contribute to the development of a newly established research group and participate in shaping its scientific direction
• An interdisciplinary research environment combining computational biology, protein biochemistry, structural biology and cell biology
• Opportunities to acquire new technical skills, including computational pipeline development, HPC-based analysis and experimental protein characterization
• Access to research infrastructure and collaborative scientific networks
• Opportunities to participate in national and international conferences, publish research findings and develop an independent scientific profile
• Employee benefits according to institutional regulations
  

Required Documents (in English):

• Cover letter describing your research interests, motivation and relevant experience (maximum one page)
• Brief description of previous research achievements and technical expertise (optional if covered sufficiently in the CV)
• Contact details for two or three academic referees

Number of offers available 1 Company/Institute The International Institute of Molecular Mechanisms and Machines Polish Academy of Sciences Country Poland State/Province Mazowieckie City Warsaw Postal Code 02-247 Street Marcina Flisa 6 Geofield