Assistant / Research Assistant (f/m/x)

Mossakowski Medical Research Institute, Polish Academy of Sciences; Polska; On-site; PLN 90,000 - 130,000; Full time

Benefits offered by this job

Ubezpieczenie zdrowotne

Możliwość uczestnictwa w konferencjach

Wsparcie socjalne i programy rozwoju

Job summary

Mossakowski Medical Research Institute, Polish Academy of Sciences prowadzi zaawansowane badania z zakresu neurogenetyki i genomiki funkcjonalnej. Poszukujemy specjalisty do pracy nad in vitro modelami neuronów i organoidów mózgowych, z silnym zapleczem w biologii komórki i bioinformatyce.

Zakres obejmuje rozwijanie modeli od pacjentów, analizy multi-omics, a także udział w tworzeniu platformy dostępu do modeli organoidów oraz prezentacje wyników na konferencjach naukowych.

Qualifications

• Wymagany tytuł magistra z dziedziny biologii lub nauk medycznych.
• Publikacje lub współautorstwo prac naukowych jest mile widziane.
• Znajomość technik biologii komórki in vitro, molekularnej i mikroskopii konfokalnej.

Responsibilities

• Prowadzenie eksperymentów hodowli komórek (neurony ludzkie, 2D) i hodowli organoidów (mózgowe, 3D).
• Rozwijanie modeli neuronalnych i organoidów od nowych pacjentów.
• Prowadzenie badań funkcjonalnych markerów synaptycznych i epigenetycznych.
• Wspieranie zapisu i analizy danych oraz udział w publikacjach i prezentacjach na konferencjach.

Skills

Cell biology techniques

Molecular biology

Confocal microscopy

Bioinformatics methods

Education

Master's degree in biological or medical sciences

Tools

Confocal microscopy

Bioinformatics software

Statistical analysis

Job description

Mossakowski Medical Research Institute, Polish Academy of Sciences

Organisation/Company Mossakowski Medical Research Institute, Polish Academy of Sciences Department Department of Neurogenetics and Functional Genomics Research Field Biological sciences Medical sciences Neurosciences Researcher Profile First Stage Researcher (R1) Positions Other Positions Application Deadline 15 Nov 2026 - 23:59 (Europe/Warsaw) Country Poland Type of Contract To be defined Job Status Full-time Hours Per Week 40 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Reference Number SDI.111.13.2026 Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The current research program of the Department of Neurogenetics and Functional Genomics:

• functional studies of the underlying mechanisms of familial Alzheimer’s disease, with a particular focus on synaptic dysfunction, using a model based on reprogrammed human neurons and brain organoids;
• identification and comprehensive characterization (including bioinformatics) of mutations and genomic variants associated with the clinical phenotype of CUN neurodegenerative diseases, muscular, neurodevelopmental, neuropsychiatric, and related disorders;
• analysis of cellular and molecular processes (including mitochondrial function and mitophagy) underlying frontotemporal dementia (FTD) spectrum disorders caused by mutations in the PGRN , MAPT , and C9orf72 genes;
• development of new cellular models using iPSC lines derived from patients with Alzheimer’s disease (AD) caused by presenilin (PSEN1/2) mutations;

The area of the research in which the candidate would participate:

• in vitro functional studies of early pathological molecular hallmarks of Alzheimer’s disease using an organoid model and reprogrammed neurons derived from patients with familial type presenilin gene mutations, as well as with sporadic type;
• multi-omic studies of the early stages of Alzheimer's disease;
• participation in the development of a platform providing access to brain organoid models from patients with neurodegenerative diseases, for the purpose of testing research hypotheses with translational potential.

Description of job position activities:

• conducting cell culture experiments (human neurons, 2D) and organoid culture experiments (brain organoids, 3D);
• developing / establishing neuronal or brain organoid models from new patients (recruited continuously in the laboratory) strating from primary fibroblasts culture via appropriate reprogramming stages
• conducting functional studies of synaptic and epigenetic markers in vitro models;
• assisting with electrophysiological recordings (patch-clamp in whole-cell configuration) and analysis using microelectrode array (MEA) technology, as well as calcium response recordings (GCAMP8, Fura2-AM);
• active participation in the scientific and organizational activities of the Department and the Institute;
• initiative and commitment to solving experimental tasks, analyzing, interpreting, and discussing results;
• preparing publications based on the obtained results;
• representing the Department and the Institute at scientific conferences.

Requirements

Research Field Biological sciences Education Level Master Degree or equivalent

Research Field Medical sciences Education Level Master Degree or equivalent

Skills/Qualifications

• a master’s degree (or equivalent) in biological or medical sciences;
• authoring or co-authoring of scientific publications;
• proficiency in cell biology techniques ( in vitro cell culture), molecular biology, and confocal microscopy;
• good knowledge of bioinformatics methods and statistical data analysis;
• independence and excellent work organization;
• creativity, ability to work in a team;
• designating the MMRI PAS as the primary place of employment
• good or very good command of English;
• communicative command of Polish.

Specific Requirements

Additional requirements (desirable):

• experience with organoid culture methods;
• knowledge of electrophysiological measurement methods;

Languages

ENGLISH Level Excellent

POLISH Level Good

Research Field

Biological sciencesMedical sciencesNeurosciences

Internal Application form(s) needed

Internal Application Form_SDI.111.13.2026_2.pdf

• employment at one of the leading scientific institutions in Poland;
• employment contract (full-time position);
• opportunity for scientific development and independence in project management for which funding was obtained independently by the candidate;
• participation in the implementation of other projects;
• opportunity to attend conferences and to participate in internships abroad;
• additional support from the social fund (i.e. support in difficult life situations, childcare subsidies and low interest loans);
• possibility to join Employee Capital Plans (PPK);
• additional benefits such as opportunity to join a group life insurance program, medical service package, and a Multisport card on preferential terms;
• work in a good team, in a nice atmosphere;
• friendly work environment.

Work Location(s)

Number of offers available 1 Company/Institute Mossakowski Medical Research Institute, Polish Academy of Sciences Country Poland State/Province Mazovian City Warsaw Postal Code 02-106 Street Pawinskiego 5 Geofield