Chemical Manager

Thornton Tomasetti; Karachi Division; On-site; PKR 1,800,000 - 3,000,000; Full time

Job summary

Thornton Tomasetti is seeking a Chemical Manager in Karachi to support the Quality Control function. The role focuses on Cleaning Validation, Computer System Validation, and Annual Product Quality Review processes, with extensive collaboration across departments to ensure compliant QC operations.

The ideal candidate holds an M.Sc. in Chemistry (or Pharm-D) with 8–10 years in QC/QA roles, and will drive CAPA, change control, and audit readiness across the site.

Qualifications

• 8–10 years’ experience in QC/QA roles.
• Experience with Cleaning Validation and Computer System Validation.
• Familiarity with Annual Product Quality Review (APQR) and related data analyses.
• Knowledge of validation, facility, and related quality systems.

Responsibilities

• Support QC Manager in Cleaning Validation, CSV and PQR activities.
• Prepare PQR annual plan and implement it on time.
• Collect, review, analyze PQR data and report findings to senior management for CAPA.

Skills

Quality Control

Cleaning Validation

Computer System Validation

PQR

CAPA

Change Control

Risk Assessment

Audit/Inspections

QA/QC Knowledge

Education

M.Sc. Chemistry

Pharm-D

Job description

## Chemical ManagerApply: Pakistan - Karachi: Full time: Posted Today: End Date: October 10, 2026 (10 days left to apply): 31163026## **JOB DESCRIPTION:**Provide support to Quality Control Manager in managing QC activities related to Cleaning Validation, Computer System Validation and Annual PQR process. **Major Responsibilities:*** Prepare PQR (product Quality Review) Annual plan and implement it in timely manner.* Collect PQR related data from all stakeholders, review and analyse data and prepare PQR report.* Share PQR findings / observations / trends with respective sections and Senior Management for appropriate CAPA/recommendation.* **Cleaning Validation*** Preparation of Cleaning Validation Master Plan (CVMP), protocols and reports with worst case selection as per recent guidelines and products at site.* To ensure Cleaning Validation activities related with Products, Processes, and Equipment.* To provide support to QC in conducting glassware cleaning validation.* Conduct Cleaning validation and revalidation via preparing cleaning validation protocols, relevant documentation as per Master plan.* Perform and manage cleaning validation sampling activities along with QA support.* Revision of cleaning validation schedule as per production and supply priority as per their request and consensus.* **Computer System Validation:*** Prepare annual Computer System Validation Master Plan (CSVMP) of QC equipment and ensure adherence, prepare, and communicate monthly computer system validation plan to all stake holders.* Prepare protocols and reports of computer system validation and to perform computer system validation activity accordingly.* **General Responsibility:*** Review of applicable policies and align SOPs (related to PQR, cleaning validation, and computer system validation).* Implementation and compliance of all the SOPs and applicable policies and procedures.* To review and complete change control tasks with respect to Cleaning Validation, Computer System Validation and PQR.* To prepare impact assessment and risk assessment as or when required.* To provide support to other sections/departments with respect stability program and any data required for to PQR, Cleaning Validation, and Computer System Validation* To review AQR LL, HPR and other quality projects for assessment and actions related to above-mentioned sections.* To participate in self-inspection, Regional, Divisional and AQR Audits as an SME of above-mentioned sections.* To implement Audit CAPAs of above-mentioned sections in timely manner* Any other responsibility, assigned by Quality Control Manager or Head of Quality Assurance.* As an SME support will be provided to Stability Section when required.**Education/Knowledge & Experience:*** M.Sc. Chemistry / Pharm-D* 8-10 years’ experience in the same capacity* Knowledge of requirement for QC/QA activities, Cleaning Validation, Computer System Validation problem resolution skills and other all activities taking place in QC/QA including knowledge of Annual product quality review.* Knowledge regarding Validation and Facility etc.