Postdoctoral Fellow – Advanced 3D Tissue Models, Exosomes and Secretomics

Universitetet I Oslo; Oslo; On-site; NOK 550,000 - 750,000; Full time

Job summary

The University of Oslo invites applications for a Postdoctoral Fellow in Biomaterial Science (BIOMAT) within the Institute of Clinical Dentistry, Faculty of Dentistry. The position focuses on developing and applying advanced 3D in vitro models to study oral biology, disease mechanisms, tissue regeneration and biomaterial–cell interactions.

Researchers will work with spheroids, organoids and tissue‑engineered constructs, exploring microfluidic/organ‑on‑a‑chip systems and bioprinted models, and

Responsibilities

• Develop, optimize and validate advanced 3D cell culture models (spheroids, organoids, tissue‑engineered constructs).
• Establish and apply rotational 3D culture systems (e.g., CelVivo or similar).
• Design and perform experiments on cell–cell and biomaterial–cell interactions.
• Conduct secretome and extracellular vesicle/exosome analyses.
• Utilize high‑multiplex protein assays for cytokine and biomarker profiling.

Job description

Join UiO's inclusive culture as a Postdoctoral Fellow in Biomaterials, advancing 3D models for oral health research!

Postdoctoral Fellow – Advanced 3D Tissue Models, Exosomes and Secretomics

Position Details and Project Description

Biomaterial Science (BIOMAT) / Institute of Clinical Dentistry, Faculty of Dentistry, is seeking a Postdoctoral Fellow to develop and apply advanced 3D in vitro models for studies of oral biology, disease mechanisms, tissue regeneration and biomaterial–cell interactions.

The project will involve the development, characterization and application of physiologically relevant models, including spheroids, organoids and tissue‑engineered constructs, with opportunities to work with microfluidic/organ‑on‑a‑chip systems and bioprinted models.

A central component of the project will be the investigation of cellular communication through secretomics analyses, including extracellular vesicles/exosomes. Advanced cell culture, molecular biology and imaging approaches will be combined to study cellular responses and mechanisms relevant to oral disease and regenerative medicine.

The overall aim is to establish robust and translationally relevant 3D experimental models that can contribute to a better understanding of oral diseases and support the development of improved therapeutic and regenerative strategies.

More about the position

The Postdoctoral Fellow will join the Biomaterial Science (BIOMAT) department researchers and develop advanced 3D in vitro models for studies of oral biology, disease mechanisms, tissue regeneration and biomaterial‑cell interactions. The position offers opportunities for interdisciplinary collaboration, methodological development, scientific publishing, and grant preparation. The Postdoctoral Fellow will be supported in developing an independent research profile and competencies relevant to future academic and research careers.

A career development plan will be established and followed up during the appointment. If needed, The University of Oslo will facilitate the acquisition of educational competence required for an Associate Professor position.

The appointment is for 3 years.

Responsibilities

The successful candidate will:

• Develop, optimize and validate advanced 3D cell culture models, including spheroids, organoids and tissue‑engineered constructs.
• Establish and apply rotational 3D culture systems such as CelVivo or comparable platforms.
• Design and perform experiments investigating cell–cell and biomaterial–cell interactions.
• Perform secretome and extracellular vesicle/exosome analyses.
• Optimize and apply high-multiplex protein assays for cytokine and biomarker profiling in biological samples and cell‑culture supernatants.