Antibody Engineer for Antifungal Immunotherapy

Arbeidsplassen; Oslo; On-site; NOK 580,000 - 700,000; Full time

Benefits offered by this job

International scientific environment

Growth opportunities

Norwegian pension fund

Possibility of extension

Job summary

Oslo University Hospital's Department of Immunology invites applications for a 3-year researcher position funded by the South-Eastern Norway Regional Health Authority. The successful candidate will join a multidisciplinary team developing antibody-based immunotherapies against invasive fungal diseases, using antibody engineering, in vivo models and advanced imaging to study antifungal immunity.

The role includes engineering antifungal antibodies, developing antibody-based probes, and defining

Qualifications

• PhD in immunology with strong focus on B- or T-cell biology and antibody engineering.
• Experience with cloning, plasmid design, and CRISPR-Cas9 is essential.
• Proficiency in flow cytometry for single-cell sorting and phenotyping.
• Experience with BCR sequencing or bioinformatics pipelines.
• Preclinical experience with transgenic models; FELASA C or equivalent.
• Microscopy or imaging experience is advantageous.
• Experience with fungal infection models is an advantage.

Responsibilities

• Engineer antifungal antibodies to strengthen immune defense in immunocompromised hosts.
• Develop antibody-based probes and imaging tools to detect fungal targets and immune engagement.
• Study T and B cell bases of antifungal immunity using knock-in models and live imaging.

Skills

B-cell immunology

T-cell immunology

Antibody engineering

Molecular biology

CRISPR-Cas9

Flow cytometry (FACS)

BCR sequencing/bioinformatics

Preclinical transgenic models

Knock-in mouse models

Advanced imaging

Fungal host-pathogen models

Education

PhD in immunology

Tools

CRISPR-Cas9 workflows

Job description

Oslo University Hospital's Department of Immunology invites applications for a 3-year researcher position funded by the South-Eastern Norway Regional Health Authority. The successful candidate will join a multidisciplinary team developing antibody-based immunotherapies against invasive fungal diseases, using antibody engineering, in vivo models and advanced imaging to study antifungal immunity.

The role includes engineering antifungal antibodies, developing antibody-based probes, and defining