Senior Manager Local Study Operations

Biopharma Careers; Breda; On-site; EUR 120,000 - 180,000; Full time

Benefits offered by this job

Competitive salary

Bonus structure

Fixed 13th month

Holiday allowance

Health insurance

On-site gym

Restaurant with healthy food

Job summary

Amgen Breda is seeking a Senior Manager Local Study Operations to lead and develop a team of LSOMs, delivering the country clinical trial portfolio from feasibility through close-out. You will drive operational excellence, oversee study execution, and ensure quality and regulatory compliance across global and local stakeholders.

In this role you will oversee resource planning, manage LSOM and supplier performance, and collaborate with the Country-Hub Head to align strategy and portfolio

Qualifications

• Degree educated with significant clinical operations experience.
• Around 7 years of experience leading people, teams, projects, or programs within a clinical research environment.
• Proven experience delivering clinical trials within a biotech, pharmaceutical, or CRO setting.
• Experience managing clinical operations across the Netherlands, including strong understanding of local regulatory requirements around global clinical trials.
• Experience overseeing clinical research suppliers (e.g., CROs, central labs, imaging vendors).
• Fluency in English and in Dutch.
• Monthly presence in the Breda office.

Responsibilities

• Lead and develop LSOMs, building a high-performing team and strengthening capabilities to deliver increasingly complex clinical trials.
• Oversee the delivery of the country study portfolio, ensuring studies are executed on time, within scope and budget, and in line with quality and regulatory requirements.
• Monitor portfolio performance, identify risks and quality trends, and lead issue escalation, mitigation, and resolution.
• Manage LSOM and supplier performance, ensuring consistent, high-quality study execution and achievement of portfolio objectives.
• Drive resource planning and workload allocation across FTE and FSP teams to optimize delivery and align with global priorities.
• Partner with the Country-Hub Head and cross-functional stakeholders to align study strategy, support study placement decisions, and ensure successful portfolio execution.
• Foster operational excellence through continuous improvement, knowledge sharing, adoption of best practices, and digital innovation.

Job description

Career Category

Clinical

If you feel like you’re part of something bigger, it’s because you are. At Amgen our shared mission, to serve patients, drives all that we do. It is key to becoming one of the world’s leading biotechnology companies. We are global collaborators who achieve together, researching, manufacturing and delivering ever-better products that reach over 10 million patients worldwide. It’s time for a career you can be proud of.

SENIOR MANAGER LOCAL STUDY OPERATIONS

At Amgen Breda medicines are labelled, assembled, stored and eventually shipped to various countries worldwide. Every day more than 1000 people with 42 different nationalities are working on supply chain processes, manufacturing, marketing and sales of our medicines and clinical research into new medicines.

What you will do

In this vital role you will lead and develop a team of Local Study Operations Managers (LSOMs), ensuring the successful delivery of the country’s clinical trial portfolio from feasibility through study close-out.

You will drive operational excellence by overseeing study execution, portfolio performance, resource planning, and quality, while fostering collaboration across global and local stakeholders to support Amgen’s clinical development strategy.

Lead, coach, and develop LSOMs, building a high-performing team and strengthening capabilities to deliver increasingly complex clinical trials.

Oversee the delivery of the country study portfolio, ensuring studies are executed on time, within scope and budget, and in line with quality and regulatory requirements.

Monitor portfolio performance, identify risks and quality trends, and lead issue escalation, mitigation, and resolution.

Manage LSOM and supplier performance, ensuring consistent, high-quality study execution and achievement of portfolio objectives.

Drive resource planning and workload allocation across FTE and FSP teams to optimize delivery and align with global priorities.

Partner with the Country-Hub Head and cross-functional stakeholders to align study strategy, support study placement decisions, and ensure successful portfolio execution.

Foster operational excellence through continuous improvement, knowledge sharing, adoption of best practices, and digital innovation.

What we expect of you

• Degree educated with significant clinical operations experience.
• Around 7 years of experience leading people, teams, projects, or programs within a clinical research environment.
• Proven experience delivering clinical trials within a biotech, pharmaceutical, or CRO setting.
• Experience managing clinical operations across the Netherlands, including strong understanding of local regulatory requirements around global clinical trials.
• Experience overseeing clinical research suppliers (e.g., CROs, central labs, imaging vendors).
• Strong understanding of global clinical trial operations and local regulatory requirements.
• Ability to manage resources, budgets, timelines, and performance metrics.
• Excellent stakeholder management, communication, and cross-functional collaboration skills.
• Continuous improvement mindset with the ability to drive operational excellence and implement best practices.
• Fluency in English and in Dutch.
• Monthly presence in the Breda office.

What you can expect of us

As we work to develop treatments that take care of others, so we work to care for our teammates’ professional and personal growth and well‑being. Therefore, Amgen is regularly recognized as a Best Place To Work.

Vast opportunities to learn and move up and across our global organization.

Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act.

• Generous Total Rewards Plan comprising competitive salary, bonus structure, fixed 13th month, holiday allowance and a collective health insurance.

Focus on vitality with an on-site gym, vitality prog ram and a restaurant with healthy food.