Principal Scientist (Bioanalytics)

Lonza; Geleen; On-site; Confidential; Full time

Benefits offered by this job

Agile career culture

Inclusive workplace

Performance-based compensation

Role-specific benefits

Job summary

Lonza Geleen is seeking a Principal Scientist Bioanalytics to lead the development and execution of dedicated (Bio)analytical methods within the Analytical Development Team, ensuring QC alignment and project success.

You will supervise new team members, collaborate with internal stakeholders and clients, and contribute to pre-validation studies, SOP creation, and transfer of validated methods to QC. A GMP mindset and strong communication skills are essential.

Qualifications

• PhD and years of experience in analytical development.
• Expertise in Bioassays for mRNA-LNP.
• Experience with flow cytometry and ELISA.
• Knowledge of ICH and USP guidelines.
• Aseptic cellular work experience.

Responsibilities

• Develop and transfer bioanalytical methods for product development and QC.
• Plan and document pre-validation studies per regulatory requirements.
• Author SOPs and support cross-department documents.
• Train colleagues and transfer validated methods to QC.
• Perform routine testing for development campaigns and stability.
• Represent the Analytical Development department as SME with stakeholders and clients.

Skills

Analytical development

Flow Cytometry (FACS)

ELISA

Statistical methods

Cellular work

Leadership

Communication

Education

PhD

Tools

Sanger Sequencing

Oxford Nanopore Sequencing

qPCR

LC-MS

Job description

Geleen

As a member of the Analytical Development Team, you will be in charge of developing and running dedicated (Bio)analytical methods, while assisting with other ongoing developments, based on customer needs. You are responsible to ensure analytical development is in line with quality control. You are accountable for the performance and results of the assigned projects. Thereby you support and supervise new members of the group.

Netherlands, Geleen

Principal Scientist Bioanalytics

Location: Geleen

As a member of the Analytical Development Team, you will be in charge of developing and running dedicated (Bio)analytical methods, while assisting with other ongoing developments, based on customer needs. You are responsible to ensure analytical development is in line with quality control. You are accountable for the performance and results of the assigned projects. Thereby you support and supervise new members of the group.

What You Will Get

• An agile career and dynamic working culture
• An inclusive and ethical workplace
• Compensation programs that recognize high performance
• A variety of benefits dependent on role and location
• The full list of our global benefits can be also found on https://www.lonza.com/careers/benefits .

The full-time annual base pay for this position in The Netherlands is expected to range between 60.750,- EUR and 85.050,- EUR. Initial salary placement within this range will be determined based on role‑related factors such as experience, qualifications, and expected contribution.

What You Will Do

• Transfer, optimize, and develop bioanalytical methods to support product development and quality control.
• Plan, execute, and document method pre‑validation studies in accordance with applicable regulatory requirements.
• Authoring of Standard Operating Procedures (SOPs)
• Technical support in cross departmental documentation (validation documents, development documents)
• Train colleagues and transfer pre‑validated methods to the GMP‑compliant Quality Control (QC) department.
• Perform routine testing for development campaigns and stability studies as required.
• Represent the Analytical Development department as a Subject Matter Expert (SME) in interactions with internal stakeholders and external clients.
• Represent the Analytical Development department as a Subject Matter Expert (SME) and/or Project Team Member (PTM) in interactions with internal stakeholders and external clients.

What We Are Looking For

• PhD + multiple years of experience in analytical development
• Expertise in analytical development of Bioassays in the area of mRNA‑LNP.
• Practical and theoretical experience in analytical method development and validation, with a strong focus on potency assays in accordance with ICH and USP guidelines in the field of RNA‑LNP bioassays. Especially regarding Flow Cytometry (FACS) and ELISA
• Deep understanding of statistical methods relevant to analytical method development and validation.
• Practical experience with cellular work (aseptic handling)
• Ability to lead junior staff and further their development
• Be a collaborative team player with a flexible and proactive mindset who thrives in a dynamic environment and views changing priorities as opportunities.
• Curiosity and enthusiasm for implementing and evaluating new analytical technologies.
• Very good communication skills and interaction with project organization and customers.

Preferred

• Initial experience with GMP‑compliant documentation and laboratory practices.
• Hands‑on and deep theoretical experience with at least two of the following analytical techniques including trouble shooting: Sanger Sequencing, Oxford Nanopore Technology Sequencing, Quantitative PCR (qPCR), Liquid Chromatography coupled with Mass Spectrometry
• Initial experience in project management and/or customer management within an analytical development environment.

About Lonza

At Lonza, our people are our greatest strength. With 30+ sites across five continents, our globally connected teams work together every day to manufacture the medicines of tomorrow. Our core values of Collaboration, Accountability, Excellence, Passion and Integrity reflect who we are and how we work together. Everyone’s ideas, big or small, have the potential to improve millions of lives, and that’s the kind of work we want you to be part of.

Innovation thrives when people from all backgrounds bring their unique perspectives to the table. At Lonza, we value diversity and are committed to creating an inclusive environment for all employees. If you’re ready to help turn our customers’ breakthrough ideas into viable therapies, we look forward to welcoming you on board.

Reference: R78337