Postdoc: Tumor-Selective NOTCH Cancer Therapy

Maastricht University; Maastricht; On-site; EUR 41,000 - 64,000; Full time

Benefits offered by this job

12-month contract

Holiday allowance 8%

Year-end bonus 8.3%

ABP pension

Gym facilities

International environment

Job summary

Maastricht University invites applications for a Postdoctoral Researcher – Preclinical Cancer Drug Development to establish therapeutic potential in advanced in vivo cancer models. You will determine efficacy, mechanism of action and tumour-microenvironment responses, and explore how these drugs can improve treatment when combined with standard therapies and immunotherapy.

You will join the Radiotherapy department at Maastricht University and Maastro Radiation Institute, contributing to a 3-year

Qualifications

• PhD in cancer biology with peer-reviewed publications.
• Hands-on in vivo cancer models; Article 9 qualification required.
• Interest in translational oncology, innovation and preclinical drug development.
• Experience with tumour immune microenvironment and/or immuno-oncology preferred.
• Experience with molecular and -omics analysis of tumours.
• Experience with combination treatments, pharmacology/PK-PD or radiotherapy; Article 5B irradiation certification preferred.

Responsibilities

• Design, perform and analyse in vivo breast-cancer studies in immune-competent TNBC models.
• Establish drug dose, schedule and conditions for combination strategies including chemotherapy, radiotherapy and immunotherapy.
• Quantify tumour response, tolerability and survival and relate to PK/PD and target engagement.
• Characterise treatment-induced changes in tumour microenvironment via molecular, histological and imaging approaches.
• Identify pharmacodynamic and response biomarkers to support patient stratification and translation.
• Communicate results through meetings, presentations and publications; support translational studies and funding applications.
• Support teaching activities related to Oncology

Skills

PhD in cancer biology

In vivo cancer models

Translational oncology

Immuno-oncology

Omics analysis

Combination therapies

Radiotherapy experience

Education

PhD in cancer biology

Job description

Maastricht University invites applications for a Postdoctoral Researcher – Preclinical Cancer Drug Development to establish therapeutic potential in advanced in vivo cancer models. You will determine efficacy, mechanism of action and tumour-microenvironment responses, and explore how these drugs can improve treatment when combined with standard therapies and immunotherapy.

You will join the Radiotherapy department at Maastricht University and Maastro Radiation Institute, contributing to a 3-year