Postdoc: In Vivo Preclinical Cancer Drug Development (TNBC)

Maastricht University; Maastricht; On-site; EUR 44,000 - 69,000; Full time

Benefits offered by this job

12-month contract (1.0 FTE) with two‑k

Gross monthly salary €3,706–€5,760

8% holiday allowance

8.3% year-end bonus

29 vacation days plus 4 extra days and

Job summary

Maastricht University invites applications for a Postdoctoral Researcher in Preclinical Cancer Drug Development. You will lead in vivo TNBC studies, optimize drug combinations with chemo-, radiotherapy and immunotherapy, and investigate tumour microenvironment changes to inform clinical translation.

Collaborating with the Radiotherapy department and Maastro Radiation Institute, you will contribute to a 3-year Dutch Cancer Society-funded project starting 01-01-2027, with a strong focus on

Qualifications

• PhD in cancer biology with peer‑reviewed work in a cancer field.
• Hands-on in vivo cancer models, including design and tissue collection; Article 9 qualification or equivalent required.
• Strong interest in translational oncology and preclinical drug development.
• Experience with tumour immune microenvironment/immuno-oncology preferred.
• Experience with -omics analyses (transcriptomics, single-cell, spatial) and integrating with in vivo response.
• Experience with combination therapies and pharmacology/PK-PD; irradiation certs preferred.

Responsibilities

• Design, perform and analyse in vivo breast cancer studies in TNBC models.
• Establish drug dosing and schedules for combination strategies.
• Quantify tumour response, tolerability and survival; relate to PK-PD and target engagement.
• Characterise treatment-induced changes in tumour microenvironment using molecular and imaging approaches.
• Identify pharmacodynamic biomarkers to support translation and patient stratification.
• Communicate results in meetings, publications and funding applications.
• Support Oncology teaching activities.

Skills

In vivo cancer models

Translational oncology

Immuno-oncology

Omics analysis

PK-PD awareness

Education

PhD in cancer biology

Job description

Maastricht University invites applications for a Postdoctoral Researcher in Preclinical Cancer Drug Development. You will lead in vivo TNBC studies, optimize drug combinations with chemo-, radiotherapy and immunotherapy, and investigate tumour microenvironment changes to inform clinical translation.

Collaborating with the Radiotherapy department and Maastro Radiation Institute, you will contribute to a 3-year Dutch Cancer Society-funded project starting 01-01-2027, with a strong focus on