Postdoc: BRCA1-Driven Precancer & In Vivo Modeling
SIGRA
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Benefits offered by this job
Job summary
Netherlands Cancer Institute invites applications for a postdoctoral researcher to join a Gray Foundation Team Science project examining BRCA1-deficient precancer. You will map genetic and phenotypic landscapes in prophylactic mastectomy specimens and validate driver candidates in vivo.
This role combines human tissue biology, single-cell genomics, spatial imaging, and functional mouse modeling to connect findings to clinical cancer interception. Amsterdam campus.
Qualifications
- You hold a PhD in Cancer Biology, Cell Biology, Molecular Biology, or a closely related discipline.
- You are a rigorous, analytical, and quantitative scientist with a genuine interest in mechanistic in vivo research.
- Experience with mouse models, lentiviral systems, CRISPR, or mammary gland biology is an advantage.
Responsibilities
- Lead work on BRCA1-associated precancer using a novel mouse model to study early events of tumor initiation.
- Quantify clone persistence, expansion, and progression via whole-mount imaging at single-cell resolution.
- Investigate immune-epithelial interactions in precancerous ducts and their impact on tumorigenesis.
- Translate discoveries into functionally validated driver candidates for cancer interception.
Skills
Education
Tools
Job description
Netherlands Cancer Institute invites applications for a postdoctoral researcher to join a Gray Foundation Team Science project examining BRCA1-deficient precancer. You will map genetic and phenotypic landscapes in prophylactic mastectomy specimens and validate driver candidates in vivo.
This role combines human tissue biology, single-cell genomics, spatial imaging, and functional mouse modeling to connect findings to clinical cancer interception. Amsterdam campus.
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