PhD Student Biophysics of Cellular Immunity

StudentJob; Utrecht; Presencial; EUR 36 000 - 45 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Pension ABP

Openbaar vervoer vergoeding

Ontwikkelingsmogelijkheden

Reiskostenvergoeding

Resumo da oferta

UMC Utrecht zoekt een gemotiveerde PhD-student Biophysics of Cellular Immunity in het Vorselen Lab voor onderzoek naar biophysische krachten in immuunresponsen. De positie is een opleidingsplaats met 36 uur per week, met focus op mechanische regulatie van immuunfuncties en de ontwikkeling van nieuwe analysecapsules.

Je zult data-analyses pipelines ontwikkelen en experimenten uitvoeren met immuunassays en hoog-resolutie fluorescentie-imaging, met een verwachte verdeling van 25% labwerk en 75%

Qualificações

• Mastergraad in biophysica of gerelateerd vakgebied.
• Ervaring met programmeren en beeldanalyse.
• Hands-on wet lab ervaring met celkweek en fluorescent imaging.
• Zorgvuldige, proactieve en flexibele werkhouding met verantwoordelijkheidsgevoel.
• Uitstekende communicatieve en organisatorische vaardigheden, zelfstandig en in teamverband.

Responsabilidades

• Ontwikkelen van analysepipeslines voor hogere verwerkings-snelheid van cellulaire krachten.
• Uitvoeren van immuunassays en hoog-resolutie fluorescence imaging.
• Balans tussen experimenten (25%) en analyse (75%).

Conhecimentos

Programming and image analysis

Wet lab ervaring

Communicatieve vaardigheden

Formação académica

Master in biophysica / biophysics gerelateerd

Ferramentas

Flow cytometrie

Fluorescent imaging

Descrição da oferta de emprego

Functiebeschrijving

Functiefamilie (intern)

UMCU - In opleiding (niet Fuwavaz)

Functienaam (extern)

PhD Student Biophysics of Cellular Immunity

Dienstverband

Opleidingsplaats

Aantal uren per week (minimaal)

36

Aantal uren per week (maximaal)

36

Salarisschaal (maximaal)

Schaal OIO's: € 3217 - € 4077

Samenvatting

We offer a position for an ambitious PhD student who is interested in research on the interface of biophysics and cellular immunology.

Functie inhoud

Mechanical forces have emerged as key regulators of immune functions. In the Vorselen Lab, we develop new technologies to tune the physical information that cells receive and to measure cellular forces. We combine this approach with high-resolution microscopy and molecular biology approaches. Together, this combination provides a very detailed readout of immune cell behavior and helps us understand the regulation of immune processes by physical forces in health and disease.
In this project, you will focus especially on developing new analysis pipelines to allow increased throughput analysis of cellular forces during phagocytosis and by therapeutic cytotoxic T cells. You will conduct experiments combining immune assays and high-resolution fluorescence imaging to obtain the required data. The balance of experiments and analysis is expected to be 25% and 75% respectively. Together, this approach is expected to reveal new insights into the regulation and functional role of biophysical forces by immune cells. The new tools and insights from this research will be a step towards assessing the potential of biophysical parameters as biomarkers.

Afdeling

You will work in the laboratory of Dr. Daan Vorselen which is focused on biophyiscs and quantitative innate immunity. We are hosted in the computational immunology cluster within the Center for Translational Immunology (CTI) at the UMC Utrecht. The Vorselen group (https://vorselenlab.com/) is composed of a small group with diverse academic backgrounds. The CTI is a well facilitated department with experts in all fields of immunology. We are structured to facilitate bench-to-bed side research. The CTI, or withing the UMCU/UU, we have state-of-the-art research facilities, including flow cytometry and imaging.

Profiel

We're looking for a motivated, enthusiastic candidate who is excited by quantitative approaches to cellular immunology research.

• A master's degree (or equivalent) in biophysics, bionanoscience or bioinformatics (and biocomplexity), or a degree in life sciences combined with clear evidence of quantitative skills.
• Experience with programming and image analysis and excitement to build new image analysis pipelines
• Hands-on wet lab experience, including cell culture and fluorescent imaging.
• A meticulous, proactive, and flexible working style, with a strong sense of responsibility.
• Excellent communication and organizational skills, and the ability to work independently and as part of a team.

Uitgelichte arbeidsvoorwaarden

• A salary between € 3.217,- and € 4.077,- gross per month (salary scale OIO's), based on full-time employment (36 hours).
• Year-end bonus of 8.3% and holiday allowance of 8%.
• Pension insurance with ABP. We take care of approximately 70% of the monthly contribution.
• 100% public transport reimbursement. Are you coming on foot, by bike or by car? You will then receive a reimbursement of € 0.18 per km (by car up to a max. Of 40 km one way).
• Possibilities to develop yourself personally and professionally.
• The option to select additional employment benefits in exchange for gross salary, such as purchasing a bicycle and memberships.

Locatie

UMC Utrecht

Aanvullende informatie

Vereiste opleiding

8. Academisch

Specialisme

Research

Vereiste ervaring

Starter (geen ervaring)

Aanvrager

Voor- en achternaam

Daan Vorselen

Zakelijk e-mailadres

[e-mail]

Telefoonnummer

088 75 543 06

Salarisomschrijving

Tussen €3.217 en €4.077 Per maand

Vaardigheden

• Je beheerst Nederlands

Opleiding

HBO

Wat wij bieden

Salaris: €3.217,- tot €4.077,-