PhD: Mitochondrial Dysfunction in Enterovirus CNS Disease

Amsterdam UMC; Amsterdam; Sur place; EUR 36 000 - 45 000; Plein temps

Avantages offerts par ce poste

End-of-year bonus

Secondments to UiO

Bike scheme

Public transport reimbursement

Résumé du poste

Amsterdam UMC invites applications for a Doctoral Candidate position within the MERIT MSCA training programme to study mitochondrial dysfunction in enterovirus CNS disease using brain and neuromuscular organoids.

The project aims to reveal how EV-A71 alters mitochondria, ROS and metabolism, and to link these changes to neuronal and neuromuscular function, with guidance from Dr. Adithya Sridhar and Prof. Dasja Pajkrt.

Qualifications

• Master's degree in biomedical sciences, infection, immunity or related fields.
• experience working with mammalian cell culture, qPCR, and bioinformatics are preferred
• excellent oral and written communication skills in English (minimum C1/C2 CEFR level)
• an interest in working in a multidisciplinary research group
• have not resided/carried out work or studies in the Netherlands for more than 12 months in the 36 months immediately before 1 April 2027 (transnational mobility rule).

Responsabilités

• to identify changes to the mitochondria (localisation, number, size) using super-resolution microscopy;
• to evaluate ROS production and its consequences on respiration and bioenergetics;
• to sketch the transcriptomic changes with a focus on mitochondria-specific genes and pathways;
• to link viral infection-induced mitochondrial changes to functional effects using electrophysiology.

Connaissances

Mammalian cell culture

qPCR

Bioinformatics

English proficiency

Formation

Master's degree in biomedical sciences

Description du poste

Amsterdam UMC invites applications for a Doctoral Candidate position within the MERIT MSCA training programme to study mitochondrial dysfunction in enterovirus CNS disease using brain and neuromuscular organoids.

The project aims to reveal how EV-A71 alters mitochondria, ROS and metabolism, and to link these changes to neuronal and neuromuscular function, with guidance from Dr. Adithya Sridhar and Prof. Dasja Pajkrt.