PhD in GPRC5B Nanobody Discovery & AI-Driven Tools
Amsterdam UMC
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Job summary
Vrije Universiteit Brussel (VUB) is recruiting for a doctoral candidate embedded in the POLARIS consortium. You will generate and characterise GPRC5B-targeting nanobodies, undertake in vitro and in vivo analyses, and gain experience through planned secondments with POLARIS partner organisations. The project spans discovery to preclinical characterisation, with academic supervision by Prof.
Timo De Groof and Prof. Nick Devoogdt, and secondments at DPTX and Vrije Universiteit Amsterdam.
Qualifications
- Master's degree in life sciences, preferably molecular sciences.
- Background in molecular biology and nanobody/GPCR research.
- Excellent written and verbal English; ability to work in an interdisciplinary and international research environment.
Responsibilities
- Select GPRC5B-targeting nanobodies from immune and synthetic libraries and evaluate AI-generated candidates.
- Characterise generated nanobodies in vitro and in vivo for affinity, specificity, stability and modulatory effects.
- Investigate biodistribution of nanobodies in in vivo models.
- Characterise functional effects of nanobodies on GPRC5B signalling.
- Collaborate with POLARIS partner organisations during secondments and develop nanobodies as research tools, tracers and therapeutics.
Skills
Education
Job description
Vrije Universiteit Brussel (VUB) is recruiting for a doctoral candidate embedded in the POLARIS consortium. You will generate and characterise GPRC5B-targeting nanobodies, undertake in vitro and in vivo analyses, and gain experience through planned secondments with POLARIS partner organisations. The project spans discovery to preclinical characterisation, with academic supervision by Prof.
Timo De Groof and Prof. Nick Devoogdt, and secondments at DPTX and Vrije Universiteit Amsterdam.
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