DSP Specialist

Byondis Bio; Nijmegen; On-site; EUR 70,000 - 110,000; Full time

Benefits offered by this job

Pension scheme

30 days annual leave

Dynamic campus in Nijmegen

Company events

Job summary

Byondis, a Dutch biopharmaceutical company in Nijmegen, seeks a senior scientist for its Downstream Processing (DSP) department. You will design, execute and document experiments to purify and characterize biopharmaceutical proteins, including ADCs, and contribute to process development and transfers.

The role requires a PhD in Biotechnology/Biopharmaceutical Sciences or an MSc with at least five years’ independent experience, strong protein knowledge and bioinformatics affinity.

Qualifications

• PhD in Biotechnology, Biopharmaceutical Sciences or related discipline, or MSc diploma with five years’ experience.
• Strong expertise in biopharmaceutical purification process development and data interpretation.
• Ability to troubleshoot non-routine experiments and support colleagues with technical questions.

Responsibilities

• Document experiments and data, write and review non-routine technical reports, and present results across departments.
• Collate and analyze data using appropriate software tools; link outcomes across complex studies, identify deviations, propose causes and solutions.
• Contribute to process development, transfers, troubleshooting and root cause investigations; ensure compliance with quality and EHS requirements.

Skills

Bio purification processes

Bioinformatics affinity

Python scripting

PyMOL/YASARA

Experimental troubleshooting

English communication

Education

PhD in Biotechnology or Biopharmaceutical Sciences

MSc with 5+ years experience

Tools

PyMOL

YASARA

Job description

Byondis is an independent Dutch biopharmaceutical company, based in Nijmegen, that focuses on developing innovative medicines against cancer and autoimmune diseases. Our values integrity, authenticity, entrepreneurship, quality and trust are very highly regarded. We are driven by one goal: to develop new treatments to improve the standard of care for patients.

The Downstream Processing (DSP) department is responsible for purification and formulation development of biopharmaceuticals and for the development of antibody-drug conjugates (ADCs). DSP plays a key role between different departments such as Upstream Processing, Analytical Development & Quality Control, Medicinal & Protein Chemistry and Manufacturing.

In close collaboration with your colleagues, you will be involved in the design, execution and documentation of experiments to purify and characterize biopharmaceutical proteins. The work includes biophysical characterization of proteins and ADCs using a multitude of analytical techniques. You will work in a stimulating group of researchers and will be able to grow both in your personal and scientific skills.

Your Role

As part of the DSP department, this role offers the opportunity to join a stimulating and collaborative team of international researchers and contribute to the development of biopharmaceutical processes. An interest in bioinformatics supports the development of new biological entities. Knowledge of proteins, preferably antibodies, is applied to the development and transfer of antibody purification processes from R&D to Operations.

Responsibilities include documenting experiments and data, writing and reviewing non-routine technical reports, and presenting results within and across departments. Data are collated and analyzed using appropriate software tools, linking outcomes across multiple complex studies, identifying deviations from expected results and proposing possible causes and solutions.

The role covers process development and process transfers, troubleshooting and root cause investigations. Active contribution to experimental work and process improvement goes hand in hand with working in accordance with applicable quality standards, regulatory requirements, internal procedures and EHS requirements.

Close collaboration with colleagues across different departments and participation in multidisciplinary projects provide opportunities to further develop scientific and personal skills. Technical and methodological expertise is shared by contributing to best practices, training and knowledge sharing on complex equipment and DSP methodologies.

What do you need to succeed in this role?

You hold a PhD in Biotechnology, Biopharmaceutical Sciences or a related discipline, or an MSc diploma and have at least five years of experience that enables you to work independently and advise others.

In addition, you have:

• Scientific and technical expertise in biopharmaceutical purification process development;
• Hands-on experience and willingness to actively contribute to experimental work
• Good knowledge of proteins, preferably antibodies;
• The ability to troubleshoot non-routine experiments and support colleagues with technical questions;
• An affinity for bioinformatics and experience with, or willingness to learn, molecular modeling software (such as PyMOL or YASARA) and Python scripting;
• Excellent verbal and written communication skills in English;
• The ability to work effectively in a matrix organization with changing priorities and timelines.

Personal Skills

As a creative and curious scientist, you take responsibility for your own work and commitments. A structured, results-oriented approach enables you to combine strong analytical skills with pragmatic problem-solving. Collaboration comes naturally; you openly share information, value the ideas and input of others and communicate clearly, concisely and professionally. Complex scientific concepts are translated effectively to different audiences.

You enjoy improving experiments, methods and processes and stay focused on key goals when priorities change or setbacks occur. With your hands-on mentality, positive attitude and collaborative mindset, you thrive in a cross-functional environment

Benefits and Well-Being

• Besides a competitive salary, we offer you a dynamic working environment at our state-of-the-art campus in Nijmegen.
• We also offer a pension scheme.
• 30 days annual leave based on a full-time position.
• and we organize several company events throughout the year.

Join Byondis and create the future you want, today

Contract hours: 32-40 hrs/week, preferably full-time

Applicants must be nationals of a Member State of the European Union or hold a valid work permit for the European Union.

For further information, please contact Human Resources, at tel. [phone] or by email; [e-mail].