The reduction of NMDA receptor Ca2+ permeability as a strategyto lower neuronal vulnerability to excitotoxicity

Italian Ministry of Education, University and Research; Italia; Presencial; EUR 28.000 - 36.000; Jornada completa

Descripción de la vacante

Sapienza Università di Roma invites applications for a research position in the Neurophysiology area. The project focuses on designing and executing experiments to quantify Ca2+ permeability of NMDA-type glutamate receptors expressed in heterologous systems under various pharmacological conditions.

Applicants will work with patch-clamp electrophysiology and time-resolved fluorescence microscopy to monitor Ca2+ influx and intracellular calcium changes, contributing to a high-impact neuroscience

Formación

• Eligibility criteria include scientific-professional curriculum, qualifications and publications, and an interview on cellular and molecular neurophysiology.

Responsabilidades

• Design and implement experiments to measure Ca2+ permeability of human NMDA-type glutamate receptors expressed in heterologous systems under various conditions and with different pharmacological modulators.
• Perform patch-clamp electrophysiology and time-resolved fluorescence microscopy to monitor Ca2+ dynamics.

Descripción del empleo

Organisation/Company Sapienza Università di Roma- Dip. Fisiologia e Farmacologia Vittorio Erspamer Research Field Neurosciences » Neurophysiology Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Application Deadline 5 Dec 2026 - 23:59 (UTC) Country Italy Type of Contract To be defined Job Status Not Applicable Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The scientific activities within the scope of this project will involve designing and implementing experiments to measure the Ca²⁺ permeability of human NMDA-type glutamate receptors expressed in heterologous systems under different conditions and in the presence of various pharmacological modulators. The methods employed will include patch-clamp electrophysiological recording techniques combined with time-resolved digital fluorescence microscopy, allowing simultaneous monitoring of Ca²⁺ inward currents and changes in intracellular free Ca²⁺ concentration.

Where to apply

E-mail https://xup-dff.cloud/Home/CPService

Additional Information

Eligibility criteria

• Scientific-professional curriculum (maximum score 40 points)
• Qualifications and publications (maximum score 30 points)
• Interview on topics of cellular and molecular neurophysiology, as well as on the candidates' previous scientific activity (maximum score 30 points)
• Those who have obtained at least 50/70 in the evaluation of points a) and b) are admitted to the interview

• Italy

Eligibility of fellows: country/ies of residence:

• NORTH AMERICA