Postdoctoral Researcher

Università degli Studi di Genova; Genova; On-site; EUR 31,000 - 37,000; Full time

Job summary

The Istituto Giannina Gaslini in Genoa, Italy, invites applications for a postdoctoral researcher to study in vivo assessment of cell-based and gene-corrected therapies for genetic immune diseases. The successful candidate will quantify engraftment and persistence of modified cells in preclinical models in close collaboration with the Center for Autoinflammatory Diseases and Immunodeficiency.

Applicants must have a PhD and experience with mouse in vivo models, cell biology, and preclinical work;

Qualifications

• PhD in a relevant field with strong experience in mouse in vivo models.
• Experience with cell biology techniques (primary cell culture, FACS) and preclinical models.
• Good written and spoken English; ability to work in a multidisciplinary team.

Responsibilities

• Carry out in vivo assessment of cell-based and gene-corrected therapies.
• Develop and validate strategies to quantify engraftment and persistence of modified cells.
• Collaborate with the Center for Autoinflammatory Diseases and Immunodeficiency.

Skills

Cell biology

Primary cell culture

FACS

Communication skills

English language

Education

PhD in a relevant field

Job description

The Clinical and Experimental Immunology Unit at Gaslini Institute in Genova, Italy, is looking for a highly motivated postdoctoral researcher to work on the in vivo assessment of cell-based and gene corrected therapies for genetic diseases of the immune system. The successful candidate will work on a FIS funded project and will develop and validate strategies to quantify engraftment and persistence of corrected or modified cells in preclinical models. The project is carried out in close collaboration with the Center for Autoinflammatory Diseases and Immunodeficiency of the same Institute.

Requirements

The ideal candidate must have a PhD and a strong background in mouse in vivo models.

The Successful Candidate Should Have:

• Experience with cell biology (primary cell culture, FACS) and with preclinical animal models
• Good communication skills and ability/willingness to integrate within a multidisciplinary research group
• Good knowledge of written and spoken English

The position is a two-year, full-time research contract under Art. 22 of Law 240/2010, with employee status and full social security coverage. Gross annual salary is around € 34,000. Recruitment will take place through a public call published by the University of Genova.

The Clinical and Experimental Immunology Unit combines diagnostic activity for patients with immune dysregulation with a translational research programme on rare genetic diseases of the immune system, including type I interferonopathies, and on the development of novel therapeutic strategies through gene editing.

The Unit works in close collaboration with the Center for Autoinflammatory Diseases and Immunodeficiency of Gaslini Children’s Hospital, one of the main referral centers for autoinflammatory disease in Italy and responsible for the Eurofever registry, which has longitudinally been collecting more than 4,000 patients from 69 centers in 45 countries (www.printo.it/eurofever), giving the successful candidate direct access to a large, deeply characterised patient population and to patient-derived cellular models.

The Istituto Giannina Gaslini is a multidisciplinary, highly specialized Public Children’s Hospital and Research Institute located in Genoa, Italy. The Institute is a national and international reference center with main research programs in rheumatology, immunology, and autoinflammatory diseases; innovative diagnostic-therapeutic strategies and rare diseases.