POST-DOCTORAL POSITION ON AN ERC-FUNDED PROJECT (SR-TIGET)

Ospedale San Raffaele srl; Milano; In loco; EUR 40.000 - 50.000; Tempo pieno

Descrizione del lavoro

A renowned scientific institute in Milan is seeking a highly motivated Postdoctoral Fellow to join the Liver Gene Therapy Unit. The role involves characterization of hepatocyte dynamics, in vivo genetic modification, and training younger fellows. Candidates should have a Ph.D. in life sciences with a strong publication record and experience in molecular biology. This position offers a renewable 2-year contract with competitive conditions.

Servizi

Attractive working conditions

Inclusive environment

Competenze

• Proven track record of publications in recognized journals.
• Documented experience in molecular and cellular biology.
• Experience with gene therapy is a plus.

Mansioni

• Characterization of molecular and functional heterogeneity of hepatocytes during liver growth.
• In vivo genetic modification of hepatocytes.
• Data analysis and critical interpretation of the results.
• Discussion of project results at internal and external meetings.
• Training of younger fellows in the lab.

Conoscenze

Molecular and cellular biology

Data analysis

Experience with mouse models

Formazione

Ph.D. in life sciences

Descrizione del lavoro

IRCCS San Raffaele Scientific Institute in Milan, Italy, is looking for a highly motivated Postdoctoral Fellow to join the Liver Gene Therapy Unit, SR-Tiget. The goal of our lab is to study liver dynamics during growth and homeostasis to devise permanent in vivo genetic engineering of hepatocytes for the treatment of metabolic diseases in pediatric patients. To this aim, we combine single-cell, organoids, and multiomic analyses, including the latest-generation spatial transcriptomics, together with advanced genetic engineering tools. The ERC-funded project builds on our recent findings that most hepatocytes are quiescent during liver growth, and only a fraction of them generate most of the adult tissue (Milani, Starinieri et al., J Hepatol 2025 https : / / tinyurl.com / 2x2nnf4r). We aim now to characterize molecular programs of mouse and human proliferating and quiescent hepatocyte subsets and assess their susceptibility to in vivo lentiviral gene delivery and targeted genome editing.

Main activities

• Characterization of molecular and functional heterogeneity of hepatocytes during liver growth
• In vivo genetic modification of hepatocytes
• Data analysis and critical interpretation of the results
• Discussion of project results at internal and external meetings

Training of younger fellows in the lab

Training of younger fellows in the lab.

Who we are looking for

• Ph.D. in life sciences
• Proven track record of publications in recognized journals
• Documented experience in molecular and cellular biology
• Previous experience with mouse models or gene therapy is a plus

Work details

• Type of contract: renewable collaboration
• Duration: 2 years
• Place of work: IRCCS San Raffaele Hospital, Via Olgettina, number 60 - Milan (Italy)

At San Raffaele Scientific Institute, a world-renowned center of excellence for clinical and scientific activities, we believe that considering diversity and promoting an open and inclusive environment is crucial to our success. We are committed to ensure that equal employment opportunities are provided and based on merit without regard to age, religion, sex, disability, medical condition, sexual orientation, cultural and social backgrounds, gender identity or expression, national or ethnic origin, or any other legally recognized status entitled to protection under applicable laws. We offer attractive conditions and rewards appropriate to an internationally competitive research organization.