In Situ Cryo-ET Research Internship in Structural Biology

Human Technopole; Milano; In loco; EUR 7600 - 10.000; Part-time

Vantaggi offerti da questo lavoro

Canteen service

Guest House upon availability

Training opportunities

Descrizione del lavoro

Human Technopole (HT) invites applications for an internship in the Structural Biology Center, Milan. The project focuses on developing and applying cryogenic electron tomography workflows to study cellular organization in disease-relevant models, combining sample prep, imaging and computational analysis.

The intern will support tissue and organoid work, help process cryo-ET data, and document results within a collaborative research team. MSc candidates with cryo-EM experience are preferred.

Competenze

• MSc in Biochemistry, Molecular Biology, Structural Biology, Biophysics or related discipline.
• Hands-on experience with biological sample preparation for cryogenic electron microscopy, including cryo-EM grid preparation.
• Practical research experience with mammalian cell culture and fluorescence microscopy, including analysis of biological imaging data.

Mansioni

• Support preparation and optimization of biological samples for cryo-FIB milling and cryo-ET.
• Contribute to implementation and optimization of workflows for in situ structural investigation of tissue material.
• Support processing, analysis and interpretation of cryo-ET datasets.
• Document experimental activities and present results within the research team.

Conoscenze

Cryo-EM sample prep

Mammalian cell culture

Fluorescence microscopy data analysis

Linux environments

Python programming

Molecular biology techniques

Formazione

MSc in Biochemistry/Biophysics/Structural Biology

Strumenti

Cryo-EM

Linux

Python

Descrizione del lavoro

Human Technopole (HT) invites applications for an internship in the Structural Biology Center, Milan. The project focuses on developing and applying cryogenic electron tomography workflows to study cellular organization in disease-relevant models, combining sample prep, imaging and computational analysis.

The intern will support tissue and organoid work, help process cryo-ET data, and document results within a collaborative research team. MSc candidates with cryo-EM experience are preferred.