Postdoctoral Researcher

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A Post-Doc position is available at the Translational Research Laboratory (AUSL-IRCCS of Reggio Emilia, Italy) - PI: Dr. Francesca Reggiani – Molecular Immunology Unit

The Translational Research Laboratory is a multifunctional unit that aims to deepen knowledge of the molecular mechanisms involved in oncological pathologies, starting from information in the genome of cancer and microenvironment cells to combined functional genomics approaches. The main areas of expertise available in the lab are molecular and cellular biology, functional genomics, biostatistics, and bioinformatics.

Type of position

Postdoc position for 1 year, renewable for 3 years.

Required or preferred skills

· A Ph.D. in Biological Sciences or related disciplines is mandatory

·A consolidated experience in cell cultures and basic molecular and cellular biology techniques is required

·A previous experience in tumor models and an immunology background will be preferred

·Previous experience in the processing and/or analysis of next-generation sequencing (NGS) data (RNA-seq, ChIP-seq, scRNA-seq, ATAC-seq) will be considered a plus

·The successful candidate is expected to be highly motivated, capable of executing experiments independently

·Good attitude to teamwork

·Excellent communication skills and proficient English

· Knowledge of the Italian language is mandatory

The successful candidate will join Dr. Francesca Reggiani's team to clarify the complex transcriptional network priming Natural Killer anti-tumor immunity in TNBC patients. The project is a translational research study. The candidate will have the opportunity to work in a multidisciplinary team with the collaboration of the Medical Oncology and Pathology Units of the AUSL-IRCCS Hospital. The project foresees the application of the state-of-the-art approaches in the study of tumor microenvironment and functional genomics, including CRISPR-based techniques, organoids, immune assays, ex vivo bioreactors, Digital-Spatial Profiling, and multi-parameter flow cytometry.

The candidate will be responsible for patient sample handling and analyses, as well as developing novel functional assays to validate the NK role in anti-TNBC immunity. Moreover, he/she will be involved in gene expression modulation experiments by applying CRISPR-based systems, and preparing samples for subsequent NGS analyses (RNA-seq, ChIP-seq, ATAC-seq).

The position has been funded by MFAG2023 to Dr. Reggiani, and the Fellowship will be available for one year (+3Ys), starting in October 2025.

Application procedure

To apply, the candidate should send to francesca.reggiani2@ausl.re.it:

•Names of two referees (including contact information)

Additional info

Please feel free to ask for any further information and send your CV to Dr. Francesca Reggiani at francesca.reggiani2@ausl.re.it

Seniority level

• Seniority level

  Internship

Employment type

• Employment type

  Full-time

Job function

• Job function

  Research, Analyst, and Information Technology

• Industries

  Hospitals and Health Care

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