Scientist - UPD (Mammalian)- Biosimilar

Enzene Biosciences Ltd; Maharashtra; On-site; INR 1,200,000 - 1,800,000; Full time

Job summary

Enzene Biosciences Ltd. seeks an experienced Upstream Mammalian Bioprocess Engineer to lead cell culture development and scale-up activities. The role emphasizes design and execution of media/feed screenings, ambr250 optimization, and bioreactor culture across fed-batch and perfusion processes.

Candidates will plan and supervise daily operations, apply aseptic techniques, and review data with cross-functional teams. Strong communication and teamwork are essential in this fast-paced environment.

Qualifications

• 8–11 years of experience in biotechnology or biochemical engineering.
• Experience in mammalian cell culture and scale-up activities.
• Ability to work in cross-functional teams in a fast-paced setting.

Responsibilities

• Design and execute media/feed screenings and optimizations using ambr250 and bioreactor culture.
• Develop late-stage upstream processes including fed-batch and perfusion.
• Plan, assign, and supervise daily operations to ensure proper experiment execution.
• Work with aseptic techniques and cell culture across lab scales.
• Review ongoing experimental data daily and communicate results.
• Collaborate with cross-functional teams and present findings effectively.

Skills

Mammalian cell culture

Fed-batch processes

Perfusion processes

Ambr250 experience

WAVE bioreactors

ATF systems

Cell counting (Cedex, Vi Cell)

Good communication

Team collaboration

Education

M.Tech/M.Sc. in Biotechnology/Biochemical Engineering

Tools

ambr250

Cedex

Vi Cell

Osmometer

Job description

• Design and execute media/feed screenings and optimizations using ambr250 and bioreactor culture
• development, including fed batch and perfusion cell culture processes.
• Planning, assigning, and supervising daily operations to ensure proper experiment execution
• Experience with aseptic techniques, cell culture in various lab-scale formats, small to medium scale
• bioreactors, and cell counting methods and equipments like Cedex, Vi Cell, Osmometer
• Handling of Mammalian cell culture using bench top, single use bioreactor and high throughput
• systems such as ambr250, WAVE bioreactors and ATF systems.
• Excellence in cell culture process development by Fed batch as well as Perfusion process.
• with both glass and single-use cell culture technologies
• Daily review of ongoing experimental data
• Reviewing functional PDR, TTD etc.
• Good interpersonal, verbal and written communication skills.
• Excellent communication and presentation skills and aptitude for problem solving
• Act as an effective and committed team player

Responsibilities

Role & responsibilities - Upstream (Mammalian)

• Design and execute media/feed screenings and optimizations using ambr250 and bioreactor culture
• development, including fed batch and perfusion cell culture processes.
• Planning, assigning, and supervising daily operations to ensure proper experiment execution
• Experience with aseptic techniques, cell culture in various lab-scale formats, small to medium scale
• bioreactors, and cell counting methods and equipments like Cedex, Vi Cell, Osmometer
• Handling of Mammalian cell culture using bench top, single use bioreactor and high throughput
• systems such as ambr250, WAVE bioreactors and ATF systems.
• Excellence in cell culture process development by Fed batch as well as Perfusion process.
• Bioreactor culture development including fed-batch, N-stage perfusion technologies (2 to 50L scale)
• with both glass and single-use cell culture technologies
• Daily review of ongoing experimental data
• Reviewing functional PDR, TTD etc.
• Good interpersonal, verbal and written communication skills.
• Excellent communication and presentation skills and aptitude for problem solving
• Act as an effective and committed team player

Experience & Qualification

• 8 to 11 years of experience with M.Tech/M.Sc. degree in biotechnology/Biochemical Engineering, Biochemistry, Biology or a related scientific discipline.
• Ability to work and collaborate in cross functional teams, research, development, manufacturing in a fast pace and dynamic team setting.