Scientist - DMPK

o2h; Ahmedabad District; On-site; INR 1,500,000 - 2,500,000; Full time

Job summary

o2h seeks a senior life sciences professional with robust ADME expertise to lead in vitro assays and analytical method development. You will work across biology, ADME, and chemistry teams to deliver integrated drug discovery support, including data analysis, documentation, and collaboration with external partners.

A strong background in LC-MS/MS and cell culture is essential. The role emphasizes high quality data, troubleshooting, and working in a fast-paced biotech environment, with

Qualifications

• Master's in Lifescience with 7+ years of experience with LC-MS/MS, HPLC, and bio-analytical studies.
• Strong understanding of laboratory techniques, analytical instrumentation, and scientific principles.
• Experience in biotechnology labs including cell culture and in vitro ADME assays.
• Ability to troubleshoot experiments and maintain data quality.
• Excellent teamwork and communication across multidisciplinary teams.

Responsibilities

• Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and protein binding.
• Develop and execute LC-MS/MS analytical methods.
• Support development and validation of new ADME assays.
• Analyze data using GraphPad Prism, MS Excel, and Sciex.
• Prepare experimental documentation and reports.
• Coordinate with collaborators for PK studies and in vivo work when applicable.
• Present results in internal meetings and cross-functional discussions.
• Collaborate across biology, ADME, and chemistry teams to provide integrated support.
• Assist with lab operations and inventory management.

Job description

• Perform routine in vitro ADME assays such as microsomal stability, plasma stability, solubility, permeability, CYP inhibition, and plasma protein binding assays

• Develop, optimise, and execute analytical methods using LC-MS/MS and complementary detection modalities (absorbance/fluorescence-based assays)

• Support development and validation of new ADME assays to expand the group’s scientific capabilities

• Process and analyse experimental data using GraphPad Prism, MS Excel, and mass spectrometry software platforms (e.g., Sciex)

• Prepare clear experimental documentation, study summaries, and reports for internal teams and external collaborators

• Coordinate with third-party collaborators for pharmacokinetic (PK) studies, including in vivo animal studies where applicable

• Present experimental results and scientific observations in internal meetings, project reviews, and cross-functional discussions

• Work closely with colleagues across biology, and ADME groups to provide integrated drug discovery support alongside chemistry teams

• Support laboratory operations including reagent ordering, inventory management, assay consumables tracking, and coordination of laboratory logistics

• Master's in Lifescience with 7+ years of working experience with LC-MS/MS, HPLC, bio-analytical studies etc.

• Strong understanding of laboratory techniques, analytical instrumentation, and underlying scientific principles

• Practical experience working in biotechnology laboratories including cell culture facilities and in vitro ADME assay environments

• Good theoretical and practical knowledge of cell culture systems (established cell lines) and ADME assays such as microsomal stability, permeability, CYP inhibition, plasma stability, and plasma protein binding

• Ability to troubleshoot experimental challenges and apply sound scientific judgment

• Self-driven and capable of managing multiple tasks while working within demanding project timelines

• Strong attention to detail and commitment to maintaining high scientific and data quality standards

• Excellent interpersonal skills with the ability to collaborate effectively across multidisciplinary teams

• Strong communication skills for interacting with internal teams, collaborators, and stakeholders

• Highly organised with the ability to function effectively in a fast-paced research environment

• Curiosity, enthusiasm for science, and a desire to contribute to innovative drug discovery programs

• A positive and collaborative mindset with the ability to contribute to a supportive and high-performance team culture at o2h