Principal Scientist- Integrated Drug Discovery

Yashraj Biotechnology Ltd; Navi Mumbai; Sur place; INR 1 200 000 - 2 400 000; Plein temps

Résumé du poste

Yashraj Biotechnology Ltd. in Navi Mumbai seeks a lead scientist to drive iPSC disease modeling and differentiation programs, ensuring reproducible results and regulatory readiness across labs and partner sites.

You will mentor cross-functional teams, oversee process development from research to scalable manufacturing, and champion ALCOA+++ and GMP compliance while coordinating with regulatory meetings and project portfolios.

Description du poste

• Reprogramming somatic cells to establish disease and healthy and disease iPSC lines, ensuring reproducibility and quality compliance throughout the process.
• Differentiating iPSC lines to target derivatives (e.g., cardiac, neural, skin cell types) using lineage-specific protocols
• Developing and validating NAM models which are Fit for Purpose and Context of Use (CoU).
• End-to-end characterization of differentiated cells including lineage marker expression by immunofluorescence, flow cytometry, and RNA/protein-based assays.
• Development and validation of CIVMs– Complex in vitro models and validation e.g. organoid, organ on chip.
• Knock in knock out studies using CRISPR technology.
• Documentation and maintenance of detailed records for all characterization assays to ensure traceability and regulatory compliance.
• Drive the QMS process as per the ISO 9001 and 13485 compliance.
• Set scientific vision and drive strategic research direction for iPSC disease modeling, differentiation technologies, and translational applications.
• Lead and mentor cross-functional teams in designing, optimizing, and scaling iPSC manufacturing and differentiation processes using cutting-edge techniques.
• Oversee process development from early-stage research to non-cGMP-ready manufacturing, ensuring scalability, compliance, and technology transfer.
• Guide project portfolio prioritization, establish milestones, and proactively manage timelines, budgets, and resources for high-impact internal and external programs
• Function as a key scientific reference, providing expert advice, troubleshooting, and decision-making support for junior and senior scientists across multiple active projects.
• Represent scientific programs at regulatory meetings, conferences, and strategic partner engagements, shaping industry standards and responding to agency inquiries.
• Champion innovation in assay development, process engineering, and automation for iPSC platforms, with a focus on next-generation manufacturing solutions.
• Take accountability for global technical alignment, troubleshooting complex scientific and operational challenges across company sites or partner collaborations.
• Foster a culture of continuous improvement and high data integrity, driving quality control, safety standards, and compliance with regulatory guidelines.
• Responsible for ALCOA+++ and GMP compliance practices.