NGS Lead

MS Clinical Research; Bengaluru; On-site; INR 3,500,000 - 6,000,000; Full time

Job summary

MS Clinical Research seeks a seasoned Next-Generation Sequencing (NGS) Lead to head our NGS operations in Bengaluru. The candidate will oversee a lab team, optimize workflows, and deliver high-quality sequencing solutions using Illumina and Oxford Nanopore platforms.

The role requires over 10 years in life sciences/genomics with hands-on NGS library prep, sequencing, and troubleshooting, plus strong leadership and data interpretation skills.

Qualifications

• Over 10 years of life sciences and genomics experience with hands-on NGS library prep and sequencing.
• Strong leadership and ability to manage an NGS laboratory team.
• Experience with Illumina and Oxford Nanopore platforms.

Responsibilities

• Lead and manage the NGS laboratory team to ensure timely, accurate project delivery.
• Plan and execute library preparation and sequencing workflows for Illumina instruments.
• Optimize sequencing protocols for metagenomic, whole-genome, RNA-seq, exome-seq, and small RNA-seq applications.
• Troubleshoot and resolve issues during library prep, sequencing, and data analysis.
• Perform nucleic acid extraction and quantification across diverse samples.
• Ensure QC using Qubit, TapeStation, and other methods.
• Develop and document SOPs for ISO compliance and audits.
• Provide technical guidance on NGS experimental design and data interpretation.
• Deliver training and webinars to customers and team members.
• Collaborate with product support on reagent and sequencing-system issues.

Skills

NGS platforms

Library preparation

Team leadership

Illumina platforms

Oxford Nanopore

PCR / qPCR

Data analysis

Troubleshooting

Education

MTech/PhD in Genetics or related

Job description

Job Title:

Next-Generation Sequencing (NGS) Lead

Job Summary:

We are seeking a highly skilled and experienced professional to lead our Next-Generation Sequencing (NGS) operations. The ideal candidate will have over 10 years of experience in life sciences and genomics, with extensive hands‑on expertise in NGS library preparation, sequencing, and troubleshooting. This role involves managing a team, optimizing workflows, and delivering high-quality sequencing solutions using Illumina and Oxford Nanopore platforms.

Key Responsibilities:

• Lead and manage the NGS laboratory team, ensuring timely and accurate project delivery.
• Plan and execute library preparation and sequencing workflows for Illumina Sequencers.
• Optimize protocols for various sequencing applications, including metagenomic sequencing, whole-genome sequencing, RNA‑seq, exome‑seq, and small RNA‑seq.
• Perform troubleshooting and resolve issues during library preparation, sequencing, and data analysis.
• Conduct nucleic acid extraction and quantification from diverse sample types using advanced techniques.
• Ensure quality control through Qubit, Agilent TapeStation, and other analytical methods.
• Develop and standardize workflows and maintain detailed documentation, including SOPs and experimental plans, for ISO compliance and audits.
• Provide technical guidance to internal and external stakeholders on NGS experimental design and data interpretation.
• Deliver technical training, webinars, and presentations to customers and team members.
• Collaborate with product support teams to address reagent and sequencing system issues.

Required Skills and Qualifications:

• Extensive experience with NGS platforms and techniques, including Illumina (MiSeq, NextSeq, NovaSeq etc)
• Proficiency in library preparation techniques such as Nextera, TruSeq, and NEB workflows.
• Strong molecular biology skills, including PCR, qPCR, and DNA/RNA quantification.
• Familiarity with microarray techniques, including gene expression and array CGH assays.
• Proven ability to troubleshoot and optimize complex laboratory workflows.
• Experience in team management and leadership roles.

Preferred Qualifications:

• MTech/Ph.D in Genetics, Biotech, Molecular Biology or related fields
• Publications in peer‑reviewed journals highlighting expertise in genomics or molecular biology.
• Experience in customer‑facing roles or technical support in the genomics field.
• Experience in Bioinformatics for data QC, data analysis specifically for metagenomics.

Why Join Us?

• Work in a cutting‑edge genomics environment with advanced technologies.
• Collaborate with a dynamic team of scientists and technical experts.
• Contribute to impactful projects in genomics and life sciences.