Director - In vitro ADME, Met-ID

Syngene International; Bengaluru; On-site; INR 4,000,000 - 7,000,000; Full time

Job summary

Syngene International in Bangalore seeks a Director - In Vitro ADME, MET-ID to lead the In vitro ADME and Biotransformation group within DMPK. You will steer Integrated Drug Discovery projects and drive scientific excellence across therapeutic areas.

The role requires a PhD with 10+ years or M.Pharm with 17+ years, strong leadership, and ability to collaborate with cross-functional teams. Based in Bangalore, it offers challenging opportunities in a safety-conscious, innovative environment.

Qualifications

• Extensive experience in designing and interpreting data from in vitro ADME assays.
• Demonstrated ability to design mechanistic ADME studies to address liabilities of new chemical entities.
• Strong leadership and mentorship of scientists and research staff.

Responsibilities

• Lead the In vitro ADME and Biotransformation group within the DMPK function.
• Act as a DMPK project leader for Integrated Drug Discovery programs.
• Represent the department in multidisciplinary cross-functional meetings and ensure timely, high-quality data.

Skills

In Vitro ADME

DMPK leadership

Team management

Scientific communication

Education

PhD in relevant field

M.Pharm with 17+ years

Job description

Job Location: Bangalore

Department: Discovery Biology

Date: 29 Sept 2026

Location:

Bangalore, KA, IN, 560099

Division: Discovery Services

Designation: Director - In Vitro ADME, MET-ID

Job Location: Bangalore

Department: Discovery Biology

About Syngene:

Syngene (www.syngeneintl.com) is an innovation-led contract research, development and manufacturing organization offering integrated scientific services from early discovery to commercial supply.

At Syngene, safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures and SOPs, in letter and spirit

Job Purpose

• Lead the In vitro ADME and Biotransformation group within DMPK function
• Work as a DMPK project leader for the Integrated Drug Discovery project

Key Responsibilities

• Extensive experience in designing and interpreting data from In vitro ADME assays from various projects. Demonstrated experience in designing mechanistic ADME studies to understand the potential issues / liabilities associated with the new chemical entities.
• Lead various Integrated Drug Discovery projects of various therapeutic areas for identification of drugability issues early in the program and help the team to identify and select clinical candidates.
• Represent the department in multidisciplinary /cross functional team meetings
• Ensure generation of scientifically robust and high-quality data within project timelines.
• Setting up KRA / KPI for the team members and monitoring their performance.
• Drive laboratory efficiency, productivity, and resource utilization.
• Interaction with cross functional team for smooth functioning of various assays/ studies
• Responsible for compliance related to the electronic lab notebooks, SOPs.
• Seamless client facing interactions to effectively represent Syngene
• Ability to adapt to the dynamic team environment.
• Possess the knowledge and exposure to environment, health, and safety (EHS) practices
• Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety
• Ensure environment, health, and safety (EHS) measures are imparted via training and adhered within the team

Technical/functional Skills

• Lead and oversee routine and customized in vitro ADME assays, including but not limited to metabolic stability, (microsomes, hepatocytes, S9 fractions), CYP inhibition and induction studies including time-dependent inhibition (TDI), reaction phenotyping, transporter assays, plasma protein binding, blood-to-plasma partitioning, solubility and permeability assays, metabolite identification support, Drug-drug interaction (DDI) risk assessments
• Manage, mentor, and develop a team of scientists and research associates.
• Seamless coordination with BA-DMPK group to design in-vitro ADME studies.
• Drive implementation of novel ADME technologies, methodologies, and automation platforms.
• Reporting of execution of the studies without any noncompliance.
• Preparation of study protocols, reports for IND/ NDA submissions.
• Well versed in report preparation for IND submissions.
• Understanding and knowledge about regulatory guidelines is desirable.

Educational Qualification

Ph. D with 10 years of experience or M. Pharm with 17+ years of experience.

Behavioral Skills

Candidates need to be team players.

Ready to take on new challenges, committed to work and timelines

Should have learning attitude, enthusiastic and hard worker.

Good communication skills

Equal Opportunity Employer

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodation for qualified individuals with disabilities.