Principal Scientist- Tides

Syngene International; Bengaluru; On-site; INR 1,500,000 - 2,400,000; Full time

Job summary

Syngene International in Bangalore is seeking a Principal Scientist to support peptide development in a PRD facility. You will generate engineering data, provide technical inputs, and contribute to ongoing projects with literature information and experimental data evaluation.

Knowledge of optimization and scale-up of anion exchange chromatography and ultrafiltration is essential. Prior oligonucleotide/peptide synthesis experience is a plus and you will help with documentation such as technology

Qualifications

• Ph.D. with 3–6 years in industry.
• Experience in Peptide/Oligonucleotide/Biological labs and scale-up.
• Knowledge of documentation for technology transfer and risk assessment.

Responsibilities

• Perform solid and solution phase peptide synthesis and conjugation.
• Support process development feasible for manufacturing.
• Execute chromatography and ultrafiltration for development activities.
• Maintain raw material and instrument spare part inventory.
• Interpret analytical data and ensure EHS compliance.
• Collaborate with cross-functional teams to complete activities.
• Prepare project documents like Process Development Reports and Tech Transfer Documents.

Skills

Peptide synthesis

Chromatography

Ultrafiltration

Technology transfer

Automated instruments

Education

Ph.D. & PDF in Chemistry/Peptide Chemistry

Tools

Automated instruments

Job description

About Syngene

At Syngene, Safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and sops, in letter and spirit

Date: 29 Sept 2026

Location:
Bangalore, KA, IN, 560099

Division: Development Services

Designation:

Principal Scientist

Job Location:

Bangalore

Department:

SMDSDM - Oligonucleotide/Peptide Scientist

About Syngene

At Syngene, Safety is at the heart of everything we do personally and professionally. Syngene has placed safety at par with business performance with shared responsibility and accountability, including following safety guidelines, procedures, and sops, in letter and spirit

Mandatory expectation for all roles as per Syngene safety guidelines

• Overall adherence to safe practices and procedures of oneself and the teams aligned
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company’s integrity & quality standards
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams, and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self
• Compliance to Syngene’s quality standards always
• Hold self and their teams accountable for the achievement of safety goals
• Govern and Review safety metrics from time to time

Job Purpose

The key objective of the role is to support the Peptide development activity in a PRD facility at Syngene. The candidate is expected to generate engineering data in the laboratory and provide technical inputs and hands on support to ongoing projects, based on thorough literature information or evaluation of available experimental data. Having good knowledge in the documentation like, Technology transfer document, risk assessment, and Investigation report. Knowledge of optimization and scale-up of anion exchange chromatography and ultrafiltration is essential. Support for the manufacturing activity. Having previous oligonucleotide/peptide synthesis knowledge is a plus.

Key Responsibilities

• Perform a solid & Solution phase Peptide synthesis and conjugation reactions.
• Support R&D for the development of the processes feasible to execute at the manufacturing facility.
• Perform a chromatography and ultrafiltration processes for the development activity.
• Maintain the raw material inventory and instrument spare part inventory.
• Interpretation and compilation of analytical data.
• Follow environment, health, and safety (EHS) requirements always in the workplace ensuring individual and lab/plant safety.
• Support manufacturing team at all stages of the execution of Peptide batches, this involves Synthesis, C & D process, Chromatography, Ultrafiltration, lyophilization and other daily activities.
• Follow up with Cross functional teams to complete the activities.
• Adhere to the Safety, Quality, Data Integrity norms as per policy.
• Prepare project related documents like, Process development report, Technology Transfer Document, and weekly updates.
  

Educational Qualification

• Ph.D. & PDF (Chemistry/Peptide Chemistry) with 3- 6yrs in industry.
  

Technical/functional Skills

• Experience in working in a Peptide/Oligonucleotide/ Biological upstream/downstream laboratory.
• Experience in setting up experiments and generate data suitable for technology transfer and execution at large scale.
• Experience in handling the automated instruments.
• Basic understanding of organic chemistry reaction principles.
• Basic understanding and knowledge on ion exchange chromatography, column purification and membrane filtration
  

Behavioural Skills

• Should have the capability to work in a team and ability to handle demonstrate a good team spirit.
• While possessing a good ability to follow instruction should also demonstrate innovative in his/her approach, good communication skills.
• Should be proactive while working on allotted responsibility.
• Flexibility to work on shifts and staggered weekends depending on work responsibility.
  

Equal Opportunity Employer

It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.