Structural Bioinformatics Lead Scientist

TN United Kingdom; Cambridge; On-site; GBP 50,000 - 90,000; Full time

Job summary

An innovative firm is seeking a highly motivated Lead Scientist to join their Bioinformatics team in Cambridge. This role involves working on cutting-edge projects in structure-based protein engineering and bioinformatics, utilizing proprietary platforms to enhance therapeutic developability. The ideal candidate will have a PhD in a relevant field, strong expertise in protein structural analysis, and proficiency in Python scripting. Join a diverse team committed to scientific innovation and make a meaningful impact in life sciences.

Qualifications

• PhD or equivalent in relevant fields with proven experience.
• Strong expertise in protein structural analysis and molecular interactions.

Responsibilities

• Work on customer projects involving in silico assessments for therapeutics.
• Utilize proprietary platforms for antibody humanization and manufacturability.

Skills

Protein Structural Analysis

Homology Modeling

Structure-Based Design

Python Scripting

Analytical Skills

Problem-Solving

Scientific Creativity

Education

PhD in Computational Chemistry

PhD in Structural Biology

PhD in Physics

PhD in Structural Bioinformatics

Tools

Linux

Job description

Structural Bioinformatics Lead Scientist, Cambridge

Lonza is a global leader in life sciences, dedicated to scientific innovation and talented collaboration. We value our people and their ideas, which help improve the world. We are seeking a highly motivated Lead Scientist with experience in Structure-based Protein Engineering and Bioinformatics to join our EDS Bioinformatics team in Cambridge, UK.

Key responsibilities:

• Work on multiple customer projects involving in silico assessments and computational design for antibody-based and recombinant protein therapeutics.
• Utilize proprietary platforms for antibody humanization, deimmunization, immunogenicity (Epibase), and manufacturability risk assessments to enhance the developability of bio-therapeutics for clients ranging from small biotech to large pharma.
• Contribute to developing innovative technologies to support R&D programs and optimize proteins for manufacturing processes.

Key requirements:

• PhD or equivalent in Computational Chemistry, Structural Biology, Physics, or Structural Bioinformatics, with proven experience.
• Expertise in protein structural analysis, homology modeling, and structure-based design, with a strong understanding of molecular interactions.
• Experience working in Linux environments and scripting (Python preferred).
• Experience in designing/developing ADCs is advantageous.
• Ability to generate high-quality reports and communicate effectively with clients.
• Strong analytical, problem-solving, and scientific creativity skills.
• Interest in process improvement through innovative solutions.
• Ability to work independently and as part of a team.
• Fluent in English, with excellent written and oral communication skills.

We are an equal opportunity employer committed to diversity and inclusion. We provide reasonable accommodations for individuals with disabilities during the application and employment process. Please contact us to request accommodations.

At Lonza, our products and services positively impact millions daily. We prioritize ethical achievement of our business results and respect for our people and environment. Join us to solve complex problems, develop new ideas, and make a meaningful difference in life sciences.