Senior Spatial Transcriptomics Scientist

Francis Crick Institute; Greater London; On-site; GBP 38,000 - 47,000; Full time

Benefits offered by this job

Generous Leave

Pension scheme

Well-being benefits

Job summary

The Francis Crick Institute is seeking a collaborative Scientist to support a lab’s spatial transcriptomics pipeline using a custom in situ sequencing platform. The role links in vivo function, gene expression, and neuronal connectivity in cortical neurons.

Appointments can be made at LRS or SLRS levels, with in-house training provided. Applicants from different career stages are welcome; the role includes developing protocols, sequencing data collection, and training users within Crick labs.

Qualifications

• Degree or equivalent in Molecular Biology, Neuroscience, Bioengineering, or related field*
• Hands-on experience with RNA/DNA handling and tissue processing (e.g., FISH, RNAscope)
• Experience operating epifluorescence or confocal microscopes
• Basic proficiency in Python, R, or MATLAB for QC and data analysis
• Ability to independently optimize complex experimental protocols and maintain records

Responsibilities

• Preparing tissue for in situ sequencing
• Developing and optimising in situ sequencing protocols
• Ordering and maintaining inventories of in situ sequencing reagents
• Developing custom gene panels for profiling cell identity and state in situ
• Collecting in situ sequencing data using a custom-built sequencing setup
• Quality control and preliminary analysis of in situ sequencing data
• Maintaining and developing the sequencing setup
• Training other users in the lab and other labs in collection and analysis of in situ sequencing data

Job description

The Francis Crick Institute is seeking a collaborative Scientist to support a lab’s spatial transcriptomics pipeline using a custom in situ sequencing platform. The role links in vivo function, gene expression, and neuronal connectivity in cortical neurons.

Appointments can be made at LRS or SLRS levels, with in-house training provided. Applicants from different career stages are welcome; the role includes developing protocols, sequencing data collection, and training users within Crick labs.