Senior Separation Scientist

Sygnature Discovery North America; Nottingham; On-site; GBP 32,000 - 46,000; Full time

Benefits offered by this job

25 days annual leave

Private Medical Insurance

Life Insurance

Employee Assistance Programme

Enhanced Family Friendly Policies

Sygnature Group Pension Scheme

1 paid volunteer day per year

Job summary

Sygnature Discovery in the UK is seeking Separation Scientists to develop new chromatographic methods and perform preparative purification using HPLC, LCMS, and related instrumentation. You will support integrated client projects and work across analytical and preparative workflows to deliver high-purity compounds.

The role focuses on method development, data interpretation, and troubleshooting of state-of-the-art equipment, contributing to efficient purification strategies and high-throughput

Qualifications

• BSc/MSc in Chemistry (or related subject) with core drug discovery and purification experience.
• Experienced in chromatographic data analysis and interpretation.
• Hands on experience of developing preparative chromatography methods using a range of techniques.
• Hands on experience in applying these methods to the isolation and purification of small molecules over a range of scales.
• Knowledge and experience of state-of-the-art preparative and analytical instrumentation with the ability to identify and troubleshoot equipment issues.

Responsibilities

• To solve chromatographic problems on a wide and diverse chemical space using state-of-the art instrumentation.
• To carry out semi-automated purification process on milligram to gram scale as well as developing bespoke analytical and preparative methods.
• To undertake preparative and analytical HPLC and LCMS on a daily basis and to troubleshoot instrument problems.
• To provide achiral purification support to medicinal chemistry project teams and comply with departmental KPIs.
• To develop high-throughput purification workflows.
• To propose and implement new initiatives to improve workflow efficiency and enhance chromatographic capabilities.

Skills

Chromatography

Data analysis

Method development

Analytical instrumentation

Purification techniques

Problem solving

Team collaboration

Education

BSc/MSc in Chemistry or related subject

Tools

HPLC

LCMS

Job description

About Sygnature Discovery

At Sygnature Discovery, we create exceptional scientific outcomes. For our customers, who bring life-changing medicines to patients; and for our people, who help make this possible.

We’re 700+ scientists from over 50 countries, working as one across Europe and North America. With no competing internal programs, we offer total confidentiality and commitment.

Over the past 20 years, we’ve earned a track record of real impact: 60+ advanced candidates, 250 patents filed, 200+ active projects. Over 90% of our customers choose to stay with us – from biotechs racing to clinic to pharma companies that need specialised expertise for targeted challenges.

About The Role

If you are interested in accelerating your career in chromatography and working with state-of-the‑art technology and instrumentation, then a role in Separation Science is for you.

Separation Scientists at Sygnature Discovery play an essential role in supporting integrated client projects as well as delivering specialist services. The growing team is looking for talented scientists to push our capabilities even further.

Your main role as a Separation Scientist will be to develop new chromatographic methods and to undertake purification by preparative HPLC alongside maintenance of both analytical and preparative instrumentation.

Role Responsibilities

• To solve chromatographic problems on a wide and diverse chemical space using state-of-the‑art instrumentation
• To carry out semi-automated purification process on milligram to gram scale as well as developing bespoke analytical and preparative methods
• To undertake preparative and analytical HPLC and LCMS on a daily basis and to troubleshoot instrument problems
• To provide achiral purification support to medicinal chemistry project teams and comply with departmental KPIs
• To develop high-throughput purification workflows
• To propose and implement new initiatives to improve workflow efficiency and enhance chromatographic capabilities

Skills & Qualifications

• You will have a BSc/MSc in Chemistry (or related subject) with core drug discovery and purification experience
• Experienced in chromatographic data analysis and interpretation
• Hands on experience of developing preparative chromatography methods using a range of techniques
• Hands on experience in applying these methods to the isolation and purification of small molecules over a range of scales
• Knowledge and experience of state-of-the‑art preparative and analytical instrumentation with the ability to identify and troubleshoot equipment issues
• Understand the influence of structural characteristics / chemistry of compounds on chromatographic behaviour
• Ability to multitask across different workflows and efficiently prioritise key tasks and requests
• Self‑motivated and capable of working independently, with a flexible approach and excellent problem‑solving skills
• Possesses a collaborative mindset and the ability to communicate in a scientific manner with attention to detail

Benefits

• 25 days annual leave (plus bank holidays)
• Private Medical Insurance
• Life Insurance
• Employee Assistance Programme
• Enhanced Family Friendly Policies
• Sygnature Group Pension Scheme
• 1 paid volunteer day per year

At Sygnature Discovery, we create exceptional scientific outcomes. For our customers, who bring life-changing medicines to patients; and for our people, who help make this possible.

We’re 700+ scientists from over 50 countries, working as one across Europe and North America. With no competing internal programs, we offer total confidentiality and commitment.

Over the past 20 years, we’ve earned a track record of real impact: 60+ advanced candidates, 200+ patents filed, 200+ active projects. Over 90% of our customers choose to stay with us – from biotechs racing to clinic to pharma companies that need specialised expertise for targeted challenges.