Senior Chromatography Scientist: Purification & Methods

Sygnature Discovery North America; Nottingham; On-site; GBP 32,000 - 46,000; Full time

Benefits offered by this job

25 days annual leave

Private Medical Insurance

Life Insurance

Employee Assistance Programme

Enhanced Family Friendly Policies

Sygnature Group Pension Scheme

1 paid volunteer day per year

Job summary

Sygnature Discovery in the UK is seeking Separation Scientists to develop new chromatographic methods and perform preparative purification using HPLC, LCMS, and related instrumentation. You will support integrated client projects and work across analytical and preparative workflows to deliver high-purity compounds.

The role focuses on method development, data interpretation, and troubleshooting of state-of-the-art equipment, contributing to efficient purification strategies and high-throughput

Qualifications

• BSc/MSc in Chemistry (or related subject) with core drug discovery and purification experience.
• Experienced in chromatographic data analysis and interpretation.
• Hands on experience of developing preparative chromatography methods using a range of techniques.
• Hands on experience in applying these methods to the isolation and purification of small molecules over a range of scales.
• Knowledge and experience of state-of-the-art preparative and analytical instrumentation with the ability to identify and troubleshoot equipment issues.

Responsibilities

• To solve chromatographic problems on a wide and diverse chemical space using state-of-the art instrumentation.
• To carry out semi-automated purification process on milligram to gram scale as well as developing bespoke analytical and preparative methods.
• To undertake preparative and analytical HPLC and LCMS on a daily basis and to troubleshoot instrument problems.
• To provide achiral purification support to medicinal chemistry project teams and comply with departmental KPIs.
• To develop high-throughput purification workflows.
• To propose and implement new initiatives to improve workflow efficiency and enhance chromatographic capabilities.

Skills

Chromatography

Data analysis

Method development

Analytical instrumentation

Purification techniques

Problem solving

Team collaboration

Education

BSc/MSc in Chemistry or related subject

Tools

HPLC

LCMS

Job description

Sygnature Discovery in the UK is seeking Separation Scientists to develop new chromatographic methods and perform preparative purification using HPLC, LCMS, and related instrumentation. You will support integrated client projects and work across analytical and preparative workflows to deliver high-purity compounds.

The role focuses on method development, data interpretation, and troubleshooting of state-of-the-art equipment, contributing to efficient purification strategies and high-throughput