Senior Scientist, Small Molecule LC-MS/MS Bioanalysis

Simbec-Orion Group; Merthyr Tydfil; On-site; GBP 65,000 - 90,000; Full time

Job summary

Simbec-Orion Group is seeking a Principal Scientist to lead small molecule LC-MS/MS bioanalysis across oncology, rare disease and clinical pharmacology studies. You will own method development and validation on triple quadrupole platforms, troubleshoot complex extraction and chromatography issues, and act as the technical authority from onboarding to final report.

This hands-on role requires setting strategy, mentoring the team on LC-MS/MS techniques, and representing Laboratory Services to

Qualifications

• Extensive hands-on LC-MS/MS (triple quadrupole) experience in regulated labs (GCP/GLP/GMP).
• Proven track record in method development and validation for small molecule bioanalysis.
• Strong extraction skills (protein precipitation, LLE, SPE) and chromatographic troubleshooting.
• Knowledge of current bioanalytical method validation guidance.
• Ability to review/approve technical documentation to GxP standards.
• Experience managing study timelines and priorities under deadlines.

Responsibilities

• Lead LC-MS/MS method development and validation from extraction strategy to validated assay.
• Troubleshoot instrument/method issues; act as technical escalation point for the team.
• Take scientific accountability for assigned studies: data integrity, regulatory compliance, final reporting.
• Review and approve protocols, validation reports, SOPs and study documentation.
• Mentor scientists in LC-MS/MS techniques.
• Represent Laboratory Services with clients, auditors and Sponsors; support Business Development with technical input.

Skills

LC-MS/MS

Method development

GxP knowledge

Regulatory compliance

Technical mentoring

Client interaction

Education

MSc/PhD in a relevant discipline

Job description

Simbec-Orion Group is seeking a Principal Scientist to lead small molecule LC-MS/MS bioanalysis across oncology, rare disease and clinical pharmacology studies. You will own method development and validation on triple quadrupole platforms, troubleshoot complex extraction and chromatography issues, and act as the technical authority from onboarding to final report.

This hands-on role requires setting strategy, mentoring the team on LC-MS/MS techniques, and representing Laboratory Services to