Lead Scientist – Small Molecule LC-MS/MS Bioanalysis

Simbec-Orion; Merthyr Tydfil; On-site; GBP 65,000 - 90,000; Full time

Job summary

Simbec-Orion is seeking a Principal Scientist to lead LC-MS/MS bioanalysis across oncology and rare diseases. You’ll own method development and validation on triple quadrupole platforms, troubleshoot complex extraction issues, and advise on study direction from onboarding to final report.

This hands-on scientific role requires mentoring the team on LC-MS/MS technique, maintaining data integrity and regulatory compliance, and representing Laboratory Services with clients, auditors and Sponsors.

Qualifications

• Hands-on LC-MS/MS experience in regulated labs (GCP/GLP and/or GMP).
• Proven track record leading method development and validation for small molecule bioanalysis.
• Strong grounding in extraction techniques (protein precipitation, LLE, SPE) and chromatographic troubleshooting.
• Working knowledge of current bioanalytical method validation guidance (GxP).
• Demonstrable ability to review and approve technical documentation to GxP standards.
• Experience managing study timelines and priorities under deadline pressure.

Responsibilities

• Lead LC-MS/MS method development and validation from extraction strategy to fully validated assay.
• Troubleshoot instrument and method issues; act as technical escalation point for the team.
• Take scientific accountability for assigned studies: data integrity, regulatory compliance, and final reporting.
• Review and approve protocols, validation reports, SOPs and study documentation.
• Mentor scientists developing their LC-MS/MS technique.
• Represent Laboratory Services with clients, auditors and Sponsors; support Business Development with technical input.

Skills

LC-MS/MS (triple quadrupole)

Bioanalysis method development

Extraction techniques

GxP knowledge

Documentation review

Project/timeline management

Education

MSc or PhD in a relevant scientific discipline

Tools

Triple quadrupole LC-MS/MS

Job description

Simbec-Orion is seeking a Principal Scientist to lead LC-MS/MS bioanalysis across oncology and rare diseases. You’ll own method development and validation on triple quadrupole platforms, troubleshoot complex extraction issues, and advise on study direction from onboarding to final report.

This hands-on scientific role requires mentoring the team on LC-MS/MS technique, maintaining data integrity and regulatory compliance, and representing Laboratory Services with clients, auditors and Sponsors.