Senior Scientist (Immune Reset)

VRS Recruitment; Slough; On-site; GBP 55,000 - 90,000; Full time

Job summary

VRS Recruitment is seeking a Research Scientist/Senior Scientist for an Immune Reset team in a global biopharmaceutical setting in the United Kingdom. The role focuses on translational and functional in vitro/ex vivo assays using primary human immune cells and patient samples to support target validation and development programs.

You will develop and execute immune-cell assays (proliferation, activation, cytotoxicity, MLR, antigen recall), analyze data, troubleshoot experiments and present

Qualifications

• Hands-on experience with functional immune-cell assays using primary human samples.
• Strong knowledge of human immunology and autoimmune disease biology.
• Proficiency with multi-parameter flow cytometry and data analysis.
• Experience with translational and target validation projects.

Responsibilities

• Develop, optimise and execute immune-cell assays for screening and target validation.
• Analyze data, troubleshoot experiments and communicate conclusions.
• Collaborate across biology, translational science and data science.
• Present findings to multidisciplinary teams and maintain safety/governance standards.

Skills

Immunology

Primary human cells

Flow cytometry

Assay development

Translational research

Data analysis

Education

BSc/MSc/PhD in Immunology

Tools

FlowJo

GraphPad Prism

Excel

ELISA/ELISpot

Luminex

MSD

Job description

Our client, a leading global biopharmaceutical organisation, is seeking a Research Scientist/Senior Scientist to join its Immune Reset team.

This is a hands‑on role focused on developing and executing translational and functional in vitro/ex vivo assays using primary human immune cells and patient‑derived samples. You will generate data supporting target validation, molecule selection and translational development programmes.

Key Responsibilities

• Develop, optimise and execute functional immune‑cell assays for screening, target validation and mechanism‑of‑action studies.
• Develop translational assays using primary human immune cells and patient samples.
• Analyse data, troubleshoot experiments and communicate clear scientific conclusions.
• Present findings to multidisciplinary and cross‑functional teams.
• Collaborate across biology, translational science and data science.
• Work to high standards of laboratory safety, compliance and sample governance.
• BSc/MSc/PhD in Immunology, Cell Biology, Molecular Biology or a related discipline.
• Strong knowledge of human immunology and autoimmune disease biology.
• Hands‑on experience with functional immune‑cell assays, such as proliferation, activation, cytotoxicity, differentiation, MLR or antigen‑recall assays.
• Experience with Fc‑mediated mechanisms such as ADCC, ADCP and/or CDC.
• Experience isolating and culturing primary human immune‑cell subsets using FACS and/or magnetic separation.
• Strong multi‑parameter flow cytometry expertise, including panel design, controls, compensation/spectral unmixing and data analysis.
• Experience with platforms such as ELISA, MSD, Luminex or ELISpot.
• Proficiency with FlowJo, GraphPad Prism, Excel and/or R.
• Strong analytical, troubleshooting and communication skills.
• Patient‑derived autoimmune/inflammatory disease samples.
• B‑cell, T‑cell, plasma‑cell or myeloid biology.
• Biologics or other therapeutic modalities.
• Spectral flow, single‑cell, imaging, transcriptomics or proteomics.

This is an excellent opportunity to join a scientifically ambitious organisation working at the forefront of immune modulation and immune reset.