Senior Scientist I - LCMS/MS

Synexa Life Sciences; Macclesfield; On-site; GBP 45,000 - 65,000; Full time

Job summary

Synexa Life Sciences (Pty) Ltd. is looking for a Senior Scientist I to lead LC-MS/MS bioanalytical laboratory studies in Macclesfield. The role involves developing and validating bioanalytical assays, ensuring regulatory compliance, and driving scientific excellence.

Qualified candidates will have a Master’s degree in a natural science or 4-5 years of relevant experience, as well as strong knowledge of analytical techniques and hands-on experience with LC/MS. Excellent English communication skills are also essential.

Qualifications

• Master’s degree in natural sciences or equivalent experience.
• Strong knowledge of LC-MS and GxP principles required.
• Advanced instrument operation experience necessary.

Responsibilities

• Lead laboratory staff and ensure compliance with GxP guidelines.
• Develop and validate bioanalytical assays for studies.
• Draft project documents ensuring high-quality reporting.

Skills

LC-MS/MS techniques

Analytical techniques knowledge

Collaboration and negotiation skills

Proficient in Mass Spectrometry

Education

Master’s degree in a natural science

Tools

Mass Spectrometer

Centrifuges

Biosafety cabinets

Incubators

Job description

Role Overview

We are seeking a Senior Scientist I to lead LC-MS/MS bioanalytical laboratory studies, develop and validate bioanalytical and immunological assays, and ensure regulatory compliance, driving high-quality study delivery and scientific excellence.

Key Responsibilities

• Lead study specific laboratory staff and ensure compliance with GxP and latest guidelines.
• Write and review SOPs and support method documentation.
• Develop, validate, and apply bioanalytical and immunological assays for pre‑clinical, clinical studies, and drug batch characterization as Responsible Scientist (RS), Study Director (SD) or Principal Investigator (PI).
• Study specific consultation, capacity management, reagent planning, inventory, troubleshooting, and training.
• Conduct and manage sample analysis, validation and method development studies.
• Draft and review project documents (e.g., lab manuals, validation plans, sample analysis reports), ensuring high‑quality reporting and client communication.
• Lead studies, manage pre‑ and post‑contract phases (change order management, reagent plans, protocols, quotes), and support revenue generation.
• Maintain ERP timesheets and unit logging, provide training, and contribute to achieving monthly revenue targets.
• Stay updated on bioanalysis trends, continuous GxP‑related training, implement EMA/FDA guidelines, assess systems for improvements, and share knowledge regularly.
• Ensure compliance with regulatory guidelines by maintaining SOPs, policies, and study documentation, and providing staff training and support.

Qualifications & Experience

Required

• Master’s degree in a natural science or 4‑5 years’ relevant experience.
• Strong knowledge of analytical techniques and hands‑on experience with LC/MS and GxP principles (GLP, GCP, GMP, GCLP).
• Proficient with advanced instruments (e.g., Mass Spectrometry).
• Proficient in following protocols, and using standard equipment (centrifuges, biosafety cabinets, incubators).
• Good command of written and spoken English, with strong collaboration and negotiation skills.

Desirable

• Experience in GxP‑accredited labs.
• Willingness to travel as needed.