Senior Scientist II - LC-MS/MS

Synexa Life Sciences; Macclesfield; On-site; GBP 45,000 - 65,000; Full time

Job summary

Synexa Life Sciences (Pty) Ltd. is looking for a Senior Scientist II to lead LC‑MS/MS bioanalytical studies in Macclesfield, United Kingdom. This role involves acting as the scientific lead, overseeing method development and validation, and ensuring compliance with GLP and GCP standards. Candidates should have an MSc or PhD in Analytical Chemistry and 5 to 10 years of experience in LC‑MS/MS bioanalysis. Strong troubleshooting skills and client interaction are essential for this position.

Qualifications

• 5 to 10 or more years of LC‑MS/MS bioanalysis experience.
• Experience leading regulated studies in a GLP/GCP environment.

Responsibilities

• Lead LC‑MS/MS bioanalytical studies ensuring integrity and compliance.
• Oversee method development, validation, and sample analysis.
• Review and interpret analytical data for quality assurance.

Skills

LC‑MS/MS method development

Analytical workflows

Troubleshooting matrix effects

Education

MSc or PhD in Analytical Chemistry or related field

Job description

Role Overview

We are seeking a Senior Scientist II (Project Leader/Principal Investigator) – LC-MS/MS Bioanalysis (PK/PD)/Responsible Scientist to lead LC‑MS/MS bioanalytical studies, ensuring scientific integrity, regulatory compliance, and successful study delivery.

Key Responsibilities

• Act as scientific lead for LC‑MS/MS bioanalytical studies conducted under GLP and GCP
• Oversee method development, validation, and sample analysis
• Review and interpret analytical data to ensure quality and compliance
• Lead investigations into analytical issues and implement corrective actions
• Ensure studies meet regulatory requirements and internal standards
• Act as primary scientific contact for clients
• Prepare, review, and approve study documentation and reports

Technical Expertise

• Strong experience in LC‑MS/MS method development and validation
• Understanding of sample preparation techniques and analytical workflows
• Ability to troubleshoot issues such as matrix effects, sensitivity, and assay variability

Qualifications and Experience

• MSc or PhD in Analytical Chemistry or related field
• 5 to 10 or more years of LC‑MS/MS bioanalysis experience
• Experience leading regulated studies in a GLP/GCP environment