Senior Scientist, Computational Chemistry

Insmed EU Careers; Cambridgeshire and Peterborough; On-site; GBP 55,000 - 75,000; Full time

Job summary

Un leader biopharmaceutique recherche un Scientifique Senior Computationnel pour appliquer votre expertise en conception assistée par ordinateur de médicaments. Vous serez impliqué dans la conception et l'optimisation de petites molécules et de biologiques pour des thérapies innovantes visant des maladies rares. Rejoignez une équipe dynamique à Insmed Cambridge et contribuez à transformer la vie des patients.

Benefits

Flexible approach to how we work

Health benefits and time-off plans

Competitive compensation package, including bonus

Equity Awards (Long-Term Incentives)

Employee Stock Purchase Plan (ESPP)

Qualifications

• Expérience de 4 à 5 ans dans un environnement industriel.
• Expertise en outils CADD et qualifications en chimie computationnelle.

Responsibilities

• Appliquer le CADD pour faire avancer les projets.
• Collaborer avec des équipes interdisciplinaires.
• Analyser et interpréter de grands ensembles de données.

Skills

Computer-Aided Drug Design (CADD)

Protein Structure Prediction

Molecular Docking

Molecular Dynamics

Data Visualization

Programming in Python

Data Analysis

Education

PhD or MSc in Computational Chemistry

Related field with industry experience

Tools

Schrödinger

MOE

Gaussian

Spotfire

Job description

Company Description

Insmed is a global biopharmaceutical company on a mission to transform the lives of patients living with serious and rare diseases. Our most valuable resource is our employees, and everything we do is motivated by a patients-first mentality. We are dedicated to growing our team with talented individuals from around the world who are willing to challenge the status quo, solve problems, and work collaboratively with a sense of urgency and compassion.

Guided by our core values of collaboration, accountability, passion, respect, and integrity, we aim to foster an inclusive, diverse, and flexible work environment, where our employees are recognized for leaning in and rolling up their sleeves. If you share our vision and want to work with the most dedicated people in the biopharma industry, come to Insmed to accelerate your career.

Recognitions

Consistently Ranked Science's Top Employer

Insmed is dedicated to creating a collaborative environment where our team can thrive. Every day, our employees turn their passion for science and research into innovative solutions for patients. That's why we've been named the No. 1 company to work for in the biopharma industry in Science's Top Employers survey for four years in a row.

A Certified Great Place to Work

We believe our company is truly special, and our employees agree. In July 2024, we became Great Place to Work-certified in the U.S. for the fourth year in a row. We are also honored to have been listed on the Best Workplaces in Biopharma, Best Workplaces in New York, PEOPLE Companies That Care, Best Workplaces for Women, Best Workplaces for Millennials, and Best Medium Workplaces lists.

Summary

At Insmed Cambridge, we are seeking a talented Computational Senior Scientist! You will bring your expertise in Computer-Aided Drug Design (CADD) to develop a new design and make platform. We discover novel targets to generate first in class therapeutics that serve patients with rare diseases, join in!

Responsibilities

• Apply CADD to drive project progression. Using computational chemistry tools and techniques (such as molecular docking, molecular dynamics, QSAR, and free energy calculations) to aid the design and optimization of small molecules, oligonucleotides, and biologics.
• Collaborate with interdisciplinary teams including Medicinal Chemists, Data Scientists, Biologists and external partners to integrate computational findings into drug discovery projects.
• Apply protein structure generation and analysis, homology modelling, and protein-ligand interaction studies to aid designing molecules.
• Contribute towards the design and development of a pioneering computational chemistry platform that integrates artificial intelligence, machine learning, and other advanced technologies for data-driven drug discovery.
• Bring and develop knowledge that allows us to get in front of and invest the latest advancements in CADD, protein structure modelling, and AI applications.
• Analyse and interpret large datasets from molecular modeling, virtual screening, and protein-ligand interaction studies to provide actionable insights for drug development programs.

What we are looking for

• PhD or MSc in Computational Chemistry, Structural Biology, Biochemistry, or a related field with industry experience (4-5 years +).
• Strong expertise in CADD tools - Schrödinger, MOE, Gaussian, or other industry-standard software) for small molecule, oligonucleotide, or biologic design.
• Hands-on experience inprotein structure prediction, homology modelling, and a keen interest in exploring novel methods for protein structure generation.
• Demonstrated ability to work with physics based methods including MD simulation and use of free energy methods.
• Proficiency in programming languages like Python or R and data visualization tools (such as Spotfire) is a plus.

Compensation & Benefits

At Insmed, we're committed to investing in every team member's total well-being, now and in the future. Our benefit programs vary by country but we offer the following to all Insmed team members, regardless of geographic location:

• Flexible approach to how we work
• Health benefits and time-off plans
• Competitive compensation package, including bonus
• Equity Awards (Long-Term Incentives)
• Employee Stock Purchase Plan (ESPP)

Additional Information

Insmed Incorporated is an Equal Opportunity employer. We do not discriminate in hiring on the basis of physical or mental disability, protected veteran status, or any other characteristic protected by federal, state, or local law. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.

Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.

Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at [e-mail] and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.

Applications are accepted for 5 calendar days from the date posted or until the position is filled.