Senior Scientist

JR United Kingdom; Slough; On-site; GBP 50,000 - 75,000; Full time

Job summary

A leading company in gene therapy is seeking an MSAT Senior Scientist I to join their dynamic team in Downstream Process Development in London. You will enhance bioprocesses, lead the development of AAV purification processes, and contribute to innovative manufacturing strategies while mentoring junior staff. This full-time role offers a competitive salary and the chance to work on cutting-edge therapies.

Qualifications

• 2+ years’ industry experience with PhD/EngD or 4+ years' with MSc/BSc.
• Experience in AAV purification, TFF, and chromatography.
• Knowledge in GMP, QbD, and statistical tools.

Responsibilities

• Lead development of downstream processes for AAV products.
• Transfer lab-scale processes to GMP facilities.
• Mentor junior team members and document development studies.

Skills

Analytical mindset

Problem-solving skills

Collaborative spirit

Education

PhD/EngD

MSc/BSc

Tools

qPCR

ELISA

HPLC

UV-spectrometry

DoE

Job description

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MSAT Senior Scientist I – Downstream Process Development (DSP)

Location: London

Full-time | Permanent

Are you ready to play a key role in advancing novel AAV gene therapies from development to commercialisation?

We’re seeking a Downstream Process Development Scientist to join a collaborative and dynamic Manufacturing Sciences and Technology (MSAT) team. You’ll help shape the future of gene therapy by driving innovation in downstream and drug product unit operations—from early-stage development through to GMP tech transfer.

About the Role

You will:

• Lead or support the development of downstream processes (chromatography, filtration, TFF, formulation, fill/finish) for novel AAV products.
• Transfer processes from lab-scale to GMP facilities.
• Execute and document development studies and protocols.
• Contribute to clinical and commercial manufacturing campaigns.
• Mentor junior team members and contribute to the knowledge base within MSAT.
• Drive technical excellence and innovation, leveraging high-throughput tools, statistical and mechanistic modelling, and DoE principles.
• Collaborate cross-functionally with manufacturing, quality, and analytical teams.

Background and Qualifications

• PhD/EngD with 2+ years’ industry experience
• OR
• MSc/BSc with 4+ years' experience in downstream process development.

Key Skills and Experience

• Experience with AAV purification, TFF, and chromatography (ion exchange, affinity, etc.).
• Understanding of GMP, QbD, and scale-up principles.
• Familiarity with statistical tools (DoE, ANOVA, t-tests, multivariate analysis).
• Analytical assay experience (qPCR, ELISA, HPLC, UV-spectrometry).
• Experience drafting SOPs, work instructions, and supporting regulatory documentation.
• Knowledge of mechanistic modelling, programming, or automated data handling is a bonus.

What We’re Looking For:

• A sharp analytical mindset and strong problem-solving skills.
• Collaborative spirit with the initiative to take ownership of work.
• A passion for improving bioprocesses through innovation and scientific rigour.

If you are interested, please apply here or feel free to send your cv to my email: [emailprotected]