Senior/Principal Bioinformatician

JR United Kingdom; Cambridge; Hybrid; GBP 50,000 - 80,000; Full time

Job summary

A leading life sciences company in Cambridge is seeking a Senior or Principal Bioinformatician to drive innovative analyses supporting drug discovery initiatives. This hybrid role requires expertise in bioinformatics, programming, and collaboration across teams to enhance drug development processes.

Qualifications

• PhD in bioinformatics, pharmacology, or related field required.
• Experience in drug development and bioinformatics essential.
• Advanced Python programming skills needed.

Responsibilities

• Lead design and execution of bioinformatic analyses for drug discovery.
• Collaborate with teams to translate business needs into analysis.
• Expand and maintain internal bioinformatic tools.

Skills

Bioinformatics

Cancer Biology

Programming in Python

Statistical Testing

Analytical Solutions

Education

PhD in Bioinformatics or related discipline

Tools

Bioinformatics Tools

Cloud Computing

Software Development Methodologies

Job description

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Client:

Hlx Life Sciences

Location:

Cambridge, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

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Job Views:

11

Posted:

25.05.2025

Expiry Date:

09.07.2025

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Job Description:

We are looking for a driven and experienced Senior or Principal Bioinformatician to lead the design and execution of bioinformatic analyses that support a variety of drug discovery initiatives. The role involves leveraging both public and proprietary large-scale patient, genomic, and functional datasets to guide and inform the company’s drug discovery priorities.

Key Responsibilities

• Provide innovative solutions to complex biological problems to gain new insights into multiple aspects of drug discovery.
• Collaborate with colleagues across the company to translate business needs into high value analysis in a timely fashion
• Work as a team to exploit and expand the data science infrastructure to meet business needs in a rapidly evolving environment.
• Expand and maintain internal bioinformatic tools.
• Work to achieve scientific deliverables and milestones at agreed quality and timescales. Identify and mitigate risks as they emerge.
• Establish appropriate communication with line manager, project team members and other stakeholders to ensure they are kept informed of workloads, issues, progress, results, innovation and developments.
• Actively demonstrate best practice and behaviours to create a positive, productive and inclusive working environment.
• Communicate analytical products and outputs to stakeholders.
• Seek input and feedback from internal and external stakeholders about their requirements and prioritize your workload.
• Interact with the Leadership team, project teams and external collaborators to aid in the delivery of projects.
• Contribute to the general duties of the company and pass on skills and knowledge to other team members.

Skills Required

[E = Essential D/E = Essential at Principal level D = Desirable]

• A PhD in bioinformatics, pharmacology, molecular biology or related scientific discipline and/or experience in bioinformatics gained in academia or industry (E)
• Knowledge of cancer biology, cancer genomics, or cancer therapeutics (E)
• Experience of using bioinformatics tools to guide drug development in areas such as biomarker identification, patient selection, mechanisms of action and resistance (E)
• A track record of developing analytical solutions to complex biological problems (E)
• Advanced knowledge of programming in Python or similar (E)
• Experience in the integration, analysis and functional interpretation of omics experiments/datasets (transcriptomics, proteomics, CRISPR) (E)
• Experience using statistical testing, including hypothesis testing and power analysis (E)

Desirable for Senior Role, Essential for Principal Role:

• Experience in the analysis of large-scale genomic and functional genomic datasets through the use of automated workflows (D/E)
• Experience in analysis of clinical data analysis (D/E)
• Experience with cloud computing and software containerization (D)
• Knowledge of current software development methodologies e.g. Scrum/Agile, CI/CD, Concurrent Version Systems (e.g. Git) (D)
• Previous experience developing, deploying and maintaining software tools (D/E)
• Previous experience of developing, deploying and/or maintaining web user interfaces and/or REST APIs (D)

This is a hybrid role that requires 3 days on-site per week