Senior/Lead Scientist, Translational Biology Immunology

CK Group; Cambridge; On-site; GBP 50,000 - 75,000; Full time

Job summary

An opportunity at a leading biopharma company in Cambridge seeks a Senior/Lead Scientist in Translational Biology Immunology. The role involves driving target validation initiatives, collaborating within multidisciplinary teams, and advancing novel therapies for immune disorders. The company offers a competitive benefits package and a state-of-the-art research environment.

Benefits

State-of-the-art R&D centre

Competitive compensation package with bonuses

26 days annual leave plus public holidays

Employer pension contributions

Private Medical Insurance for employees and family

Health and wellbeing benefits

Income protection for long-term illnesses

Group Life Insurance

Qualifications

• PhD with 2-3 years or BSc with 5 years drug discovery experience.
• Experience in planning and interpreting in vitro and in vivo studies.
• Familiarity with Home Office legislation in research.

Responsibilities

• Leading new Target Identification and Validation initiatives.
• Overseeing development of immunology assays.
• Ensuring robust translational frameworks for clinical decision making.

Skills

Immunology expertise

Drug discovery experience

Analytical skills

Interpersonal skills

Project leadership experience

Education

PhD in relevant field

BSc with significant experience

Tools

Flow cytometry

RNA expression analysis

Biochemical signalling

Job description

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Senior/Lead Scientist, Translational Biology Immunology, Cambridge

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Client:

CK Group

Location:

Cambridge, United Kingdom

Job Category:

Other

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EU work permit required:

Yes

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Job Reference:

7c69e69c2969

Job Views:

4

Posted:

02.06.2025

Expiry Date:

17.07.2025

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Job Description:

Senior/Lead Scientist, Translational Biology Immunology

CK Group are working in partnership with Nxera Pharma to recruit a Senior or Lead Scientist, Immunology, Translational Medicine, to join their Translational Biology Immunology and Metabolism group.

The ideal candidate will have immunology expertise in inflammatory or autoimmune disease, and expertise in planning and executing preclinical target validation, and translational studies to support project deliverables.

Location:

Granta Park, Cambridge.

About the company:

Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally. Their pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery “NxWave” platform to provide a sustainable source of best- or first-in-class candidates.

In Cambridge UK, Nxera have built outstanding capabilities across their platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development.

About the role:

This is an exciting opportunity to work across diverse functional groups within Nxera Pharma and with external industrial and academic collaborators. TheTranslationalBiology Team is a multidisciplinary team focused on understanding the mechanisms underlying human disease biology.

The ideal candidate will be passionate about advancing novel therapies, and biomarker strategies for the treatment of immune disorders.

Responsibilities

will include:

• Leading, executing and driving new Target Identification and Validation initiatives.
• Ensuring a robust translationalframework is embedded early in the project lifetime to drive clear decision making in the clinic.
• Oversee the development and optimisation of functional immunology assays and/or in vivo PD studies at CROs.
• Depending on experience, may act as the Project Translational lead.

Skills and Experience:

• PhD with 2-3 years drug discovery or development experience or BSc with at least 5 years drug discovery or development experience in inflammatory or autoimmune therapeutic areas.
• Extensive experience in the planning, analysis, and interpretation of in vitro and in vivo target validation and translational studies.
• Proven technical knowledge in interrogating complex immunological mechanisms using a range of in vitro and ex vivo immunological assays (e.g. isolated leukocyte subset functional assays, flow cytometry, RNA expression analysis, biochemical signalling, MSD/ELISA, imaging).
• Strong track record in human and rodent primary immune cell assay development and optimisation.
• Direct experience in the experimental design and oversight of in vivo studies and good understanding of Home Office legislation governing in vivo research.
• Proven ability to work effectively in a fast paced, multidisciplinary matrix team environment.
• Excellent interpersonal, communication and presentation skills and ability to thrive in team setting.
• Hands-on experience in managing outsourced studies with CROs or academic partners.
• Project leadership experience within a biotech or pharma setting, alternatively if coming from an academic background experience working in industry collaborations would be beneficial.
• Interest in metabolic disease or experience working in this area

What’s in it for you?

• State-of-the-art R&D centre located in the heart of the Cambridge science cluster.
• Competitive compensation package including discretionary cash bonuses.
• Eligible for grants of Restricted Stock Units.
• 26 days annual leave in addition to public holidays plus the option to purchase an additional 5 days each year.
• Employer contribution to pension.
• Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement.
• Health and wellbeing benefits including a subsidised individual gym membership.
• Income protection to cover long term absences due to ill health.
• Group Death in Service equal to 4x basic annual salary.