Senior/Lead Scientist - Quantitative Systems Pharmacology (QSP) Modeler

Vantage Research; United Kingdom; Presencial; GBP 85 000 - 125 000; Tempo integral

Resumo da oferta

Vantage Research is seeking a Senior/Lead Scientist - QSP Modeler to drive the design, development, and application of multi-scale mechanistic PK/PD and QSP models. The role spans Oncology, Immunology & Inflammation, Neuro/Ophthalmology, and Metabolic diseases, with remote work options in EU/UK.

You will lead modeling strategy, mentor junior scientists, and collaborate with global pharma and biotech clients to inform dose selection and trial design through quantitative, physiology-based

Qualificações

• PhD in a quantitative discipline (Engineering, Math, Physics, Computational Biology, Pharmacometrics) or related field.
• 3+ years (senior) or 5+ years (lead) in mechanistic PK/PD or QSP modeling in pharma/biotech/CRO.
• Strong experience with ODE-based modeling and simulation using Matlab/Python/R/Julia.
• Experience in virtual population generation, parameter estimation, nonlinear dynamics, sensitivity analysis.
• Desirable: modeling complex biologics or novel modalities; ability to lead client-facing scientific work.

Responsabilidades

• Lead end-to-end development and implementation of mechanistic PK/PD and QSP models across therapeutic areas.
• Drive modeling strategy, core biological assumptions, and quantitative frameworks for drug development questions.
• Apply modeling to modalities including TCEs, ADCs, mRNA/LNP, and virtual populations.
• Design simulations to inform dose selection, biomarker strategy, and trial design.
• Mentor junior scientists and contribute to client engagements and scientific pitches.

Conhecimentos

Mechanistic PK/PD

QSP modeling

ODE-based modeling

Client-facing leadership

Mentoring

Formação académica

PhD in quantitative discipline

Experience in pharma/biotech/CRO

Ferramentas

Matlab

Python

R

Julia

Simulink

Descrição da oferta de emprego

Senior/Lead Scientist - Quantitative Systems Pharmacology (QSP) Modeler

Europe/UK, Europe 1

Full-Time

Are you a driven and intellectually curious scientist with a passion for mechanistic modeling and simulation in drug development? Do you enjoy solving complex biological problems using quantitative approaches and influencing key decisions across the development pipeline? This role offers the opportunity to do just that within a fast-growing, high-impact scientific environment.

Vantage Research is a Contract Research Organization focused on the exciting and evolving field of Modeling & Simulation for Drug Development. Our scientific work spans multiple therapeutic areas including Oncology, Immunology & Inflammation, Neuro-degenerative and Ophthalmology diseases, Metabolic disorders such as Diabetes and Weight-loss, among others.

We are a science-first, high-performance team that builds mechanistic, physiology-based models to address critical questions across discovery, translational, and clinical stages. Working closely with global pharmaceutical and biotech partners, we aim to deliver insights that directly inform decision-making. As we continue to grow, we are looking for scientific leaders who are excited to take ownership and shape the future of our modeling capabilities.

To support our expanding portfolio, we are seeking a Senior/Lead Scientist - QSP Modeler to drive the design, development, and application of multi-scale mechanistic PK/PD and Quantitative Systems Pharmacology (QSP) models.

Role type: Remote role based out of EU//UK

Why Join Us

Join Vantage Research to work on cutting-edge drug development problems and challenges through modeling, influencing key decisions across programs. Take full ownership of projects from problem definition to delivery while working closely with leading global pharma and biotech clients. Build and scale mechanistic models across modalities and biological levels, and contribute to internal platforms that extend beyond individual programs. Be part of a fast-growing, science-driven team that values rigor, curiosity, and execution, with strong opportunities for growth, leadership, and meaningful impact in a flexible, outcome-driven environment.

You will also benefit from flexible work hours and a remote office policy that prioritizes people over process, an attractive package, and a dedicated budget for conferences. We offer a working environment where your contributions make a real difference, with strong emphasis on ownership, autonomy, participation, and long-term career growth.

Required qualifications and experience

• PhD in a quantitative discipline such as Engineering (Mechanical/Chemical/Biomedical/Aerospace/Electronics), Mathematics, Physics, Computational Biology, Pharmacometrics, or related fields.
• 3+ (Senior Scientist: 3 + years, Lead Scientist: 5+ years) years of relevant experience in mechanistic PK/PD or QSP modeling in a pharma, biotech, or CRO environment.
• Strong experience in ODE-based model development and simulation using Matlab, Python, R, Julia or similar platforms.
• Demonstrated experience in virtual population generation, parameter estimation, nonlinear dynamics, and sensitivity analysis.
• Experience in modeling complex biologics or emerging therapeutic modalities is highly desirable.
• Proven ability to independently lead quantitative projects and engage effectively in client-facing scientific roles.
• Strong analytical thinking, problem-solving skills, and ability to work in a fast-paced, collaborative environment.
• Excellent written and verbal communication skills.
• Demonstrated ability to mentor team members and contribute to scientific leadership initiatives.

What will set you apart

• Therapeutic area expertise (e.g.: Diabetes, Oncology, Infectious diseases, Immunology and Inflammation) and knowledge about important types of novel modalities (ADCs, TCEs, mRNA/LNP, siRNA etc).
• Experience in regulatory interactions (e.g. scientific advice, MIDD, IND/NDA/BLA, ICHM15 guidelines)submissions
• Published peer-reviewed articles

Scientific Leadership & Modeling

• Lead end-to-end development and implementation of mechanistic PK/PD and QSP models across therapeutic areas such as Oncology, Immunology & Inflammation, Neuro/Ophthalmology, and Metabolic diseases.
• Drive modeling strategy, key biological assumptions, and quantitative frameworks to address drug development questions.
• Apply modeling approaches to advanced therapeutic modalities including T-cell engagers (TCE), Antibody-Drug Conjugates (ADC), Bispecifics, mRNA/LNP platforms, and virtual population analyses.
• Design simulation strategies to inform dose selection, biomarker strategy, trial design, and mechanism understanding.
• Perform parameter estimation, sensitivity analysis, uncertainty quantification, and model validation.
• Serve as a primary scientific point of contact for clients and lead scientific discussions and deliver on projects on a weekly basis.
• Translate complex client questions into structured quantitative research plans.
• Ensure high-quality, timely delivery aligned with project goals and client expectations.
• Contribute to proposal development, scientific pitches, and strategic client engagement.

Platform & Capability Development

• Lead initiatives to develop and enhance internal modeling platforms, reusable model assets, and workflow tools.
• Drive innovation in modeling novel modalities, methodologies, virtual population approaches, and translational modeling frameworks.
• Contribute to scientific publications, conference presentations, and capability building.
• Mentor and guide junior scientists on modeling approaches, scientific thinking, and project execution.
• Promote best practices in coding, documentation, model validation, and scientific communication.
• Collaborate cross-functionally with biologists, clinicians, pharmacometricians, and data scientists.